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Original Article

The Effect of Pycnogenol Supplementation on Plasma C-Reactive Protein Concentration: a Systematic Review and Meta-Analysis

Omid Nikpayam1orcid, Mohammad Hossein Rouhani2orcid, Makan Pourmasoumi3orcid, Neda Roshanravan4orcid, Ehsan Ghaedi5orcid, Hamed Mohammadi6orcid
Clinical Nutrition Research 2018;7(2):117-125.
Published online: April 16, 2018

1Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran 19839-63113, Iran.

2Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.

3Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht 95655-41448, Iran.

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Correspondence to Hamed Mohammadi. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran. Mohamadihd@gmail.com
   • Revised: April 2, 2018   • Accepted: April 5, 2018

Copyright © 2018. The Korean Society of Clinical Nutrition

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The Effect of Pycnogenol Supplementation on Plasma C-Reactive Protein Concentration: a Systematic Review and Meta-Analysis
Clin Nutr Res. 2018;7(2):117-125.   Published online April 16, 2018
DOI: https://doi.org/10.7762/cnr.2018.7.2.117
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The Effect of Pycnogenol Supplementation on Plasma C-Reactive Protein Concentration: a Systematic Review and Meta-Analysis
Clin Nutr Res. 2018;7(2):117-125.   Published online April 16, 2018
DOI: https://doi.org/10.7762/cnr.2018.7.2.117
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The Effect of Pycnogenol Supplementation on Plasma C-Reactive Protein Concentration: a Systematic Review and Meta-Analysis
Image Image
Figure 1 PRISMA flow diagram of study selection process.PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
Figure 2 Forest plot of the effect of Pycnogenol supplementation on C-reactive protein.ES, effect size; CI, confidence interval.

Figure 1

Figure 2

The Effect of Pycnogenol Supplementation on Plasma C-Reactive Protein Concentration: a Systematic Review and Meta-Analysis
Table 1 Data extraction of selected studies

ns, not significant; CVD, cardiovascular disease; CRP, C-reactive protein.

Table 2 Risk of bias assessment of included studies
Table 3 Subgroup analysis to assess the effect of Pycnogenol consumption on serum hs-CRP

CVD, cardiovascular disease; CI, confidence interval; hs-CRP, high sensitivity C-reactive protein.

*Calculated by random effects model.

Table 1

Table 2

Table 3

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