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"Dietary"

Original Articles

Estimating added sugars intake among South Koreans: results from the 2023 Korea National Health and Nutrition Examination Survey
Youngmin Nam, Linxi Huang, Cho-il Kim, Jihyun Yoon
Clin Nutr Res 2026;15(3):139-148.   Published online July 31, 2026
DOI: https://doi.org/10.7762/cnr.2026.0025

Objective

This study aimed to adapt a systematic methodology for estimating the added sugars content of South Korean foods and to assess added sugars intake among South Koreans using data from the 2023 Korea National Health and Nutrition Examination Survey.
Methods
The estimation procedure developed for Australian foods was modified and applied to South Korean foods. Added sugars content was estimated for 2,314 food items using the modified 7-step estimation procedure, and these estimates were applied to dietary intake data. Mean contents of total sugars and estimated added sugars were summarized by food group. Mean intakes of total sugars and added sugars, the percentage of energy from added sugars, and the prevalence of excessive added sugars intake were estimated.
Results
According to the modified estimation procedure, 53% of food items were assigned to step 1 (total sugars=0) or step 2 (non-added sugars food groups) and therefore assigned added sugars content of zero, while 21% were assigned to step 3, in which all total sugars were classified as added sugars. Mean added sugars intake was 30.7 g/day, accounting for about half of total sugars intake (58.3 g/day). Overall, 21.2% of the population had energy intake from added sugars exceeding 10% of total energy intake, with the highest proportion observed among adolescent girls (37.9%).
Conclusion
This study provides the first nationally representative estimates of added sugars intake among South Koreans by adapting a systematic methodology. These findings provide a robust foundation for monitoring population-level added sugars intake and informing the development of targeted policies and interventions to reduce added sugars intake.
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  • 13 Download
Secular trends in dietary patterns among South Korean primary school–aged children based on the 2007–2022 Korea National Health and Nutrition Examination Survey
Adiyasuren Dookhuu, Diana Shubekova, Juhae Kim, Minji Kang
Clin Nutr Res 2026;15(3):149-160.   Published online July 31, 2026
DOI: https://doi.org/10.7762/cnr.2026.0018

Objective

This study aimed to identify dietary patterns and examine their associations with sociodemographic and lifestyle characteristics among South Korean primary school–aged children.
Methods
Data from 10,173 children aged 6–12 years who participated in the 2007–2022 Korea National Health and Nutrition Examination Survey were analyzed. Their dietary intake was assessed using a 24-hour dietary recall, and dietary patterns were derived from the energy contributions of 26 food groups through cluster analysis.
Results
Three patterns were identified: rice-based pattern (47.3%), flour-based pattern (17.7%), and diversified type (35.1%). From 2007 to 2022, the prevalence of the rice-based pattern declined substantially (56.6%–32.6%), whereas that of the diversified type markedly increased (27.3%–47.0%). Survey-weighted analyses revealed that the dietary patterns were significantly associated with age, household income, vigorous physical activity, meal-skipping, eating-out frequency, and dietary supplement use (all, P<0.05). Children following the flour-based pattern tended to be older, skip breakfast more often, and engage in less vigorous physical activities. The rice-based pattern included a higher proportion of children from low-income households, whereas the diversified type showed more favorable socioeconomic characteristics and family breakfast practices. Overall, the rice-based and flour-based patterns were associated with less favorable lifestyle behaviors than the diversified type.
Conclusion
Dietary patterns among South Korean primary school–aged children appear to be closely related to socioeconomic status and daily health behaviors. Nutrition education and public health interventions promoting balanced diets, reduced meal skipping, and healthier lifestyles during childhood are needed.
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Toward a longevity diet framework: integrating global evidence for healthy aging in the South Korean population
Soyoung Jung, Hae Jin Kang, Mijoo Choi, Yoo Kyoung Park
Clin Nutr Res 2026;15(2):91-100.   Published online April 30, 2026
DOI: https://doi.org/10.7762/cnr.2026.0015

Objective

As global life expectancy rises, the focus has shifted from longevity alone to healthy aging. Although dietary models such as the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), Mediterranean-DASH Intervention for Neurodegenerative Delay, and EAT-Lancet diets show benefits for specific health outcomes, their direct application to South Korean populations is limited by differences in dietary patterns and cultural practices. This study aimed to develop nutritional criteria for a South Korean-adapted longevity diet framework. Methods: A multiphase development approach was used, including a narrative review of major dietary models and clinical nutrition guidelines to identify key components of a longevity diet. Macronutrient distribution, food group intake, and nutrient-specific recommendations were synthesized into a structured framework. The EAT-Lancet reference diet was adjusted from 2,400 to 2,000 kcal/ day to reflect energy requirements of South Korean adults. Results: The proposed framework comprises six domain-specific recommendations, including macronutrient targets of 50%–65% carbohydrates, 10%–20% protein, and 15%–30% fat, with a 1:1 animal to plant protein ratio. Food group recommendations were tailored to South Korean dietary patterns. The framework addresses weight management, glycemic control, cardiovascular health, cognitive function, muscle function, and skin health. It emphasizes whole grains, dietary fiber, plant-based proteins, and unsaturated fats, while limiting refined carbohydrates, added sugars, and saturated fats. Conclusion: This study presents evidence-based nutritional criteria for a South Korean-adapted longevity diet framework that integrates disease prevention with functional health support to promote healthy aging.

Citations

Citations to this article as recorded by  
  • Life-course nutrition strategies for Korean middle-aged adults across biological transitions, nutritional burdens, and a community-linked precision nutrition model: a narrative review
    Yoo Kyoung Park
    Korean Journal of Community Nutrition.2026; 31(3): 215.     CrossRef
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  • 42 Download
  • 1 Crossref
Dietary intake patterns and nutritional adequacy in older adults with predialysis chronic kidney disease: a comparison by diabetes status
Jeong Eun Kim, Jisoo Kim, Yu-Jin Kwon, Jung Eun Lee, Jung Joo Lee, Ji-Won Lee, Yoo Kyoung Park
Clin Nutr Res 2026;15(2):108-116.   Published online April 30, 2026
DOI: https://doi.org/10.7762/cnr.2026.0014

Objective

Nutritional management is essential in caring for patients with chronic kidney disease (CKD), older adults at higher risk of malnutrition and comorbidities. However, data on actual dietary intake patterns in older adults with predialysis CKD, especially by diabetes mellitus (DM) status, remain limited. Methods: This cross-sectional study included 106 patients aged ≥65 years with CKD stage G3a or higher, divided into DM (n=67) and non-DM (n=39) groups. Dietary intake was assessed using a single 24-hour recall. Nutrient and food-group intakes were compared with recommended levels. Results: In both groups, energy intake was lower than recommended levels. More than half of the participants exceeded sodium limits, and approximately half consumed excess protein. Patients with DM had significantly higher protein intake and blood urea nitrogen (BUN) levels than those without DM. Most food groups, except protein foods, were consumed below recommended levels. Conclusion: Dietary patterns in older adults with predialysis CKD showed low energy intake, high sodium intake, and relatively high protein intake. Those with DM had higher protein intake and BUN levels, suggesting dietary differences by diabetes status. These findings underscore the need for age-sensitive, individualized nutritional management strategies that consider kidney function and DM status.

Citations

Citations to this article as recorded by  
  • Lessons from marine osmoregulation: Comparative perspectives on salt-sensitive hypertension and human kidney–cardiovascular protection
    Wiharjo Hadisuwarno, Dante Saksono Harbuwono, Edwin Hadinata, Pringgodigdo Nugroho, Eka Ginanjar, Dananti Kusumawindani, Raymond Rubianto Tajndrawinata, Sovia Salamah, Fahrul Nurkolis
    Current Research in Biotechnology.2026; 12: 100412.     CrossRef
  • 1,358 View
  • 35 Download
  • 1 Crossref

This study aimed to identify major dietary patterns among Korean adolescents, examine their changes over the past 16 years, and evaluate differences by sex. Data were analyzed from 7,679 adolescents aged 12–18 years who participated in the 2007–2022 Korea National Health and Nutrition Examination Survey and completed health, examination, and nutrition surveys. Dietary intake was assessed using a 24-hour recall, and cluster analysis was performed based on the energy contribution of 26 food groups. Associations between dietary patterns and nutrient intake were examined using survey-weighted linear regression. Three dietary patterns were identified: Bread, Meat, & Dairy (33.1%); Rice-based Diet (45.5%); and Convenient Foods (21.3%). Among boys, the Rice-based Diet group showed the highest prevalence of obesity and the largest proportion of low-income households, whereas the Bread, Meat, & Dairy group exhibited higher rates of supplement use and high-income status (all p < 0.05). Among girls, the Convenient Foods group tended to be older and was more likely to skip breakfast, consume alcohol, eat out daily, and perceive themselves as overweight (all p < 0.05). Over the 16-year period, adherence to the Bread, Meat, & Dairy pattern increased, whereas adherence to the Rice-based Diet pattern declined in both sexes (p < 0.01). These findings highlight a shift toward Westernized dietary patterns among Korean adolescents. Accordingly, nutrition policies and interventions should adopt tailored strategies that account for both sex and socioeconomic differences to promote healthier eating habits and support long-term adolescent health.

Citations

Citations to this article as recorded by  
  • An Exploratory Indirect Association Analysis of Dietary Supplement Use and Metabolic Risk in Korean Adolescents: A Cross-Sectional Study
    Jeoungmi Kim, Vasuki Rajaguru
    Foods.2026; 15(14): 2554.     CrossRef
  • 2,851 View
  • 35 Download
  • 1 Crossref

Review Article

Effects of the MIND Diet on the Cognitive Function of Older Adults: A Systematic Review
Seeun Kim, Eun-Hee Jang, Seungmin Lee
Clin Nutr Res 2025;14(4):318-328.   Published online October 28, 2025
DOI: https://doi.org/10.7762/cnr.2025.14.4.318

The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet is a brain-focused dietary pattern designed to prevent cognitive decline in older adults. This systematic review, conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, aimed to examine the association between the MIND diet and cognitive function in older adults. Relevant studies published between 2015 and 2024 were identified through comprehensive searches of PubMed and the Cochrane Library using keywords including “MIND diet,” “cognitive performance,” and “older adults.” From a total of 138 records screened, 11 studies met the inclusion criteria after excluding reviews, meta-analyses, editorials, and those incorporating other lifestyle interventions such as physical activity or education. These studies included 7 prospective cohort studies, 2 cross-sectional studies, 1 randomized controlled trial (RCT), and 1 case-control study, comprising a total of 17,201 participants aged 57–91 years. Across studies, at least 57% of participants were women, and in the 5 studies reporting race, more than 75% were White. Dietary intake and MIND adherence were assessed primarily via food frequency questionnaires, while cognitive outcomes were evaluated using validated instruments including the Montreal Cognitive Assessment, global cognition scores, Consortium to Establish a Registry for Alzheimer’s Disease tests, and magnetic resonance imaging. Six cohort and two cross-sectional studies reported significant associations between higher MIND adherence and better cognitive outcomes. One cohort study and the single RCT showed no effect. Excluding 2 studies with short durations (≤ 3 years), the remaining nine studies suggest consistent cognitive benefits of MIND adherence. Future studies should include systematic reviews and large-scale RCTs focusing on Asian populations.

Citations

Citations to this article as recorded by  
  • Adherence to the Mediterranean diet, inflammatory biomarkers and cognitive status in older Italian adults
    Margherita Grasso, Francesca L’Episcopo, Annamaria Fidilio, Marco Antonio Olvera-Moreira, Giuseppe Toscano, Stefano Muratore, Margherita Drago, Sabrina Musso, Veronica Bentivegna, Lucrezia Costanzo, Melannie Toral-Noristz, Raynier Zambrano-Villacres, Lisa
    Frontiers in Nutrition.2026;[Epub]     CrossRef
  • Oxidative Stress in Alzheimer’s Disease: Can Dietary Interventions Provide Neuroprotection?
    Daria Kupczyk, Rafał Bilski, Igor Kozieł, Agata Słota, Mateusz Kurek, Emilia Stablewska, Szymon Baumgart, Artur Słomka, Renata Studzińska
    Nutrients.2026; 18(15): 2436.     CrossRef
  • 6,661 View
  • 84 Download
  • 2 Crossref

Original Articles

Meal Patterns and Protein Food Utilization in Public and Private Geriatric Long-term Care Hospitals
Ga-Eun Choi, Hye-Yeon Lee, Mi-Hyun Kim
Clin Nutr Res 2025;14(4):260-269.   Published online October 28, 2025
DOI: https://doi.org/10.7762/cnr.2025.14.4.260

This study examined meal patterns and protein-rich food utilization in the foodservice practices of public and private geriatric long-term care hospitals in South Korea. Over a period of 6 months, a total of 612 daily menus (306 from each hospital type, breakfast, lunch, and dinner) were collected from four hospitals (two public, two private). Each menu was categorized by meal composition, included staple food, soup, main dish, side dishes, and kimchi. The most common meal pattern consisted of a staple food, soup, main dish, two side dishes, and kimchi. Compared with private hospitals, public hospitals offered a greater variety in meal composition, staple foods, soups, and main dishes. However, no significant differences were observed in protein foods of main dishes. Overall, meat accounted for about half, whereas fish accounted for one-third. Approximately 30% of protein foods in main dishes were processed. In side dish 1, the proportion of protein-rich foods was lower in public than in private hospitals, whereas the proportion of processed foods exceeded two-thirds in both hospital, but was significantly higher in public hospitals. Soup was the second most important protein source after the main dish, with fish as the most often used; however, processed protein foods were also common. These findings indicate that the main dish and soup are the principal protein sources, and the relatively high inclusion of fish reflects a favorable pattern. However, to ensure intake of high-quality proteins by older adults, the high reliance on processed protein foods highlights the need to reconsider foodservice practices.

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Effects of Replacing Skipped Meals With Oral Nutritional Supplement on Nutritional Status and Physical Function in Older Adults
Jiyeon Lee, Seong Ah Cho, Seoyoon Choi, Eunbi Han, Hyeri Shin, Yoo Kyoung Park
Clin Nutr Res 2025;14(3):191-203.   Published online July 29, 2025
DOI: https://doi.org/10.7762/cnr.2025.14.3.191

This study evaluated the effects of replacing skipped meals with oral nutritional supplements (ONS) on the nutritional status and functional health of older adults. A total of 29 participants aged ≥ 65 years who regularly skipped at least one meal per day were included in this single-arm study. For 8 weeks, participants consumed two packs of ONS daily (150 mL each, providing 400 kcal and 18 g of protein) as a substitute for skipped meals. Nutritional status, nutrient intake, body composition, and physical function were assessed before and after the intervention. The Nutrition Quotient for the Elderly score significantly increased from 58.97 to 63.62 (p = 0.014). Total nutrient intake, including ONS, significantly improved compared with baseline (p < 0.01). Body weight and body mass index increased significantly from 58.87 to 59.47 kg (p = 0.028) and from 23.9 to 24.18 kg/m2 (p = 0.016), respectively. Calf circumference decreased significantly from 34.1 to 33.39 cm (p = 0.010). Physical function, assessed using the Short Physical Performance Battery, showed significant improvement (p = 0.003). In conclusion, replacing skipped meals with ONS may enhance nutritional status and support functional health in older adults.

Trial Registration

Clinical Research Information Service Identifier: KCT0010184

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Cataracts are a major cause of vision impairment in older adults and pose a growing concern in aging societies. This study examined the association between dietary macronutrient intake and the odds of having cataracts among 1,619 Korean adults aged ≥ 60 years using data from the 2015–2017 Korea National Health and Nutrition Examination Survey. Cataracts were present in 51.8% of participants. Dietary intake was assessed via 24-hour recall and macronutrient intake was categorized by quartiles and energy ratios. After adjusting for covariates, individuals in the highest quartile of carbohydrate-to-energy intake (> 80%) had 41% higher odds of having cataracts (odds ratio [OR], 1.41; 95% confidence interval [CI], 0.99–2.01), with a significant trend (p for trend = 0.022). In contrast, the highest quartile of protein intake (Q3: 12%–15% energy) was associated with significantly lower odds of having cataracts in women (OR, 0.59; 95% CI, 0.40–0.88). Likewise, fat intake exceeding 18% of total energy was associated with reduced odds of having cataracts (OR, 0.69; 95% CI, 0.49–0.97). Saturated and monounsaturated fat intake also showed inverse associations with the odds of having cataracts. These results suggest that excessive carbohydrate intake, particularly when replacing fats and proteins, may increase the odds of having cataracts in older adults, especially among women. Dietary adjustments aimed at reducing the proportion of carbohydrates and increasing high-quality protein and fat intake may help prevent cataracts in aging populations. Further longitudinal studies are needed to clarify causal relationships and to inform nutritional guideline development.

Citations

Citations to this article as recorded by  
  • Development and Comparison of AI Algorithms for a Predictive Model of Cataracts: Analysis of the Korea National Health and Nutrition Examination Survey (2015–2017)
    Jiyoung Choi, Eunju Park
    Clinical Nutrition Research.2025; 14(4): 297.     CrossRef
  • 2,040 View
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  • 1 Crossref

Chronic obstructive pulmonary disease (COPD) is a major respiratory disorder characterized by irreversible airflow limitation. The role of diet in the prevention and management of COPD is receiving increasing attention. This study aimed to examine the association between the composite intake of vegetables, fruits, meat, and fish and pulmonary function as well as COPD prevalence in a representative sample of Korean adults aged ≥ 40 years using data from the 7th Korea National Health and Nutrition Examination Survey. Higher vegetable intake was associated with significantly better pulmonary function parameters, including forced vital capacity (p < 0.001), forced vital capacity percent predicted (p = 0.050), forced expiratory volume (FEV) in 1 second (FEV1; p < 0.001), FEV1 percent predicted (p = 0.038), FEV in 6 seconds (p < 0.001), and peak expiratory flow (p < 0.001). Furthermore, individuals with a high combined intake of vegetables, fruits, meat, and fish demonstrated a 0.261-fold lower COPD prevalence than those without such intake (p = 0.039). The dietary inflammatory index (DII) was significantly lower among participants without COPD than among those with COPD (mean DII = −3.6947, p = 0.002), indicating that a diet rich in anti-inflammatory nutrients can help reduce COPD risk. These findings suggest that vegetable consumption supports improved respiratory function, and a composite dietary pattern incorporating various food groups may help reduce the prevalence of COPD in the adult population.

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Similarity in Diet Quality Between Children or Adolescents With Obesity and Their Mothers
Hangsook Lee, Jieun Kim, Nayoung Kim, Hyung Gyu Park, Yoon Myung Kim, Kyung Hee Park, Hyunjung Lim
Clin Nutr Res 2025;14(3):164-173.   Published online July 25, 2025
DOI: https://doi.org/10.7762/cnr.2025.14.3.164

Obesity is a multifactorial chronic disease influenced by behavioral, environmental, genetic, and psychological factors. One primary determinant of childhood obesity is the presence of dietary factors commonly acquired through the shared home food environment, which parents can greatly influence. Thus, the present study examined the similarity in diet quality between children or adolescents with obesity and their mothers. We analyzed baseline data collected from the Intervention for Children and Adolescent obesity via Activity and Nutrition study. Seventy mother–offspring dyads were identified, which included children and adolescents with obesity aged 8–16 years and their mothers living in Seoul and Gyeonggi Province, South Korea. Food or nutrient intake and diet quality were evaluated from 3-day food records. Childhood obesity was defined as body mass index ≥ 95th percentile based on the 2007 Korean National Growth Charts. No significant difference was observed in the diet quality score between children with obesity and their mothers. However, correlation coefficients between mothers and their children’s total Diet Quality Index-International (DQI-I) score (r = 0.30) and subcategories, such as variety (r = 0.29), adequacy (r = 0.43), moderation (r = 0.45), and overall balance (r = 0.30), were positively correlated (p < 0.05). Linear regression analysis of the influence of maternal diet quality on offspring diet quality revealed that the maternal DQI-I score influenced the offspring’s DQI-I score, consistent with our prediction. Further studies with larger and more representative samples are needed to confirm the applicability of our findings to all children and adolescent populations.

Trial Registration

Clinical Research Information Service Identifier: KCT0002718

Citations

Citations to this article as recorded by  
  • Prevalence of Obesity and Overweight Among Children in Aseer Region, Saudi Arabia
    Youssef A. Alqahtani, Ayed A. Shati, Ashwag A. Asiri, Samy A. Dawood, Yazan A. Almaker, Abdulmajeed F. AlShahrani, Asma A. Nasser, Seham M. Alqahtani
    Journal of Clinical Medicine.2025; 15(1): 76.     CrossRef
  • 1,877 View
  • 26 Download
  • 1 Crossref
Previous studies have shown the inverse association between diet quality and cancer mortality. Therefore, this study aims to discover the factors that affect diet quality among cancer survivors. We analyzed the 12 years of Korea National Health and Nutrition Examination Survey data, which included 2,756 cancer survivors. We analyzed 30 factors considered to be associated with diet quality. As a result, factors related to diet quality differed between males and females. A male cancer survivor who is aged < 65, living with members of the household, living without a spouse, having a lower household income, a blue-collar worker, a beneficiary of national basic livelihood, sleeping > 9 hours a day, unaware of a nutritional fact label, insecure in food, non-user of dietary supplements, not on diet therapy, limited in activity, perceiving stress, and obese, are more likely to have lower Korean Healthy Eating Index (KHEI) scores. On the other hand, a female cancer survivor who is aged < 65, a pink-collar worker, inexperienced in nutritional education, non-users of dietary supplements, obese, and has a lower education level, and cervical or stomach cancer is prone to have lower KHEI scores. In conclusion, factors associated with diet quality among cancer survivors are sex-specific. Therefore, sex-specific factors should be considered when identifying and intervening in cancer survivors at risk for lower diet quality scores.

Citations

Citations to this article as recorded by  
  • Food and Nutrition Insecurity in Cancer Survivorship: A Global Scoping Review
    Susannah K. Ayre, Rachael J. Madders, Brooke P. Baker, Emily F. Mitchell, Belinda C. Goodwin, Elizabeth A. Johnston, Danielle Gallegos
    Cancer Medicine.2026;[Epub]     CrossRef
  • 1,402 View
  • 21 Download
  • 1 Crossref
This study aimed to evaluate the effects of functional foods containing Auricularia auricula-judae powder on gut health and clinical indicators in middle-aged and older adults. Participants were randomly assigned to either the intervention group (n = 24) or control group (n = 26), and assessments including anthropometric measurements, blood analyses, and dietary intake surveys were conducted. The intervention group consumed functional foods containing A. auricula-judae powder twice daily for 8 weeks. No statistically significant differences were observed in the gut environmental parameters between the 2 groups. However, reductions in waist circumference (p < 0.021), abdominal obesity (p < 0.006), and triglyceride levels (p < 0.016) in the intervention group were statistically significant. Additionally, an analysis of nutrient intake from meals other than the intervention food revealed a significant increase in dietary fiber (p < 0.043), vitamin B1 (p < 0.027), and folic acid (p < 0.006) intake in the intervention group. Although the intervention improved the selection of body composition and blood parameters, it failed to produce significant changes in constipation outcomes or gut environmental parameters among participants with constipation. In conclusion, the consumption of A. auricula-judae powder-based functional foods resulted in limited yet meaningful improvements, specifically in reducing waist circumference and triglyceride levels.
  • 2,172 View
  • 18 Download
Review Articles
Calcium Intake and the Pancreatic Cancer Risk: A Systematic Review and Meta-Analysis of Observational Studies
Alireza Bahrami, Milad Mohammadzadeh, Fatemeh Abdi, Amin Paydareh, Saman Khalesi, Ehsan Hejazi
Clin Nutr Res 2024;13(4):284-294.   Published online October 30, 2024
DOI: https://doi.org/10.7762/cnr.2024.13.4.284

Calcium plays a major role in apoptosis, cell proliferation, and various cellular mechanisms. It is also essential for the function of the pancreas. However, the association between calcium intake and pancreatic cancer is not clear. This study aims to clarify the links between calcium intake and pancreatic cancer risk using a systematic review and meta-analysis of observational studies. PubMed, Web of Science, Scopus, and Google Scholar were searched for eligible articles published through 31 August 2023. Case-control and cohort studies reporting the association between dietary and/or supplemental calcium intake and risk of pancreatic cancer using relative risk (RR), hazard ratio (HR), or odds ratio (OR) with 95% confidence interval (CI) were included. Meta-analysis using a random effect model was used to estimate the significance of the association. Eight studies were included. An inverse association between total calcium intake (dietary and supplement) and pancreatic cancer risk (RR, 0.83; 95% CI, 0.72–0.97; I2 = 0%) was observed. However, the association between dietary calcium intake alone and pancreatic cancer risk did not reach a statistically significant level (RR, 0.91; 95% CI, 0.78–1.06; I2 = 48%). Higher total calcium intake may reduce the risk of pancreatic cancer but the difference between sources of calcium (dietary vs. supplementation) requires further investigation. Also, due to the heterogeneity between the articles, the results of this study should be interpreted with caution.

Trial Registration

PROSPERO Identifier: CRD42022331647

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A Healthy Dietary Pattern May Have a Protective Effect Against Cardiovascular Disease Through Its Interaction With the MC4R Gene Polymorphism
Kimia Mohammadhasani, Mohammad Vahedi Fard, Mehran Yadegari, Mehdi Barati, Hossein Bahari, Elyas Nattagh-Eshtivani, Mohammad Rashidmayvan
Clin Nutr Res 2024;13(3):214-225.   Published online July 26, 2024
DOI: https://doi.org/10.7762/cnr.2024.13.3.214

Polymorphisms in the melanocortin 4 receptor (MC4R) gene with occurrence and progression of chronic diseases such as obesity and cardiovascular disease (CVD) have long been addressed but there is a lack of evidence for complex interrelationships, including direct and indirect effects of these variables. This review specifically focuses on studying the effects of healthy diet interaction and MC4R polymorphisms on the development of CVD. The quantity and quality of carbohydrates and proteins consumed are related to obesity susceptibility and cardiometabolic risk factors. A healthy dietary pattern such as a Mediterranean dietary can modulate the association between MC4R polymorphisms (rs17782313) and the risk of CVDs. Also, the Nordic diet can reduce lipid profiles such as low-density lipoprotein cholesterol (LDL-C) and total cholesterol levels. On the other hand, MC4R interaction with the dietary inflammatory index decreases high-density lipoprotein cholesterol levels and increases LDL-C and triglyceride (TG) levels. Additionally, the DASH diet decreases TG, atherogenic index of plasma, systolic blood pressure, diastolic blood pressure, and serum glucose. The interaction between MC4R genes and diets plays an important role in the development of CVD. Adherence to healthy diets such as the Mediterranean, Nordic, Anti-inflammatory, and Dash diets might be an efficient strategy to prevent CVD. The potential for personalized diets to be developed for the treatment and prevention of CVD and its related comorbidities is expected to expand as this field develops.

Citations

Citations to this article as recorded by  
  • Does the MC4R rs17782313 gene polymorphism affect the rate of exercise-induced fat oxidation?
    Mert Sakar, Çağrı Doğan, Necdet Apaydın, Gökhan İpekoğlu
    Applied Physiology, Nutrition, and Metabolism.2026; 51: 1.     CrossRef
  • Broiler Ascites Syndrome as a Potential Spontaneous Animal Model for Human Pulmonary Arterial Hypertension: A Narrative Review
    Jie Zhang, Feihu Guan, Ye Tian, Yafen Song, Min Zhang, Xiaoyue Yang, Bing Zhang, Sifan Guo, Peng Ji, Chenghuai Yang, Min Yang, Qianyi Zhang
    Life.2026; 16(5): 818.     CrossRef
  • Dietary Anthocyanin Intake and Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease: Results from the NUTRIHEP Study
    Rossella Tatoli, Rossella Donghia, Gianluigi Casimo, Pasqua Letizia Pesole, Caterina Bonfiglio
    Antioxidants.2026; 15(7): 802.     CrossRef
  • The role of micro-ribonucleic acid and small interfering-ribonucleic acid in precision nutrition for obesity management
    Wardina Humayrah, Nindy Sabrina, Megah Stefani, Nurpudji Astuti Taslim, Reggie Surya, Matthew Nathaniel Handoko, Vincent Lau, Hardinsyah Hardinsyah, Trina Ekawati Tallei, Rony Abdi Syahputra, Fahrul Nurkolis
    Clinical Nutrition ESPEN.2025; 67: 463.     CrossRef
  • Assessing the Role of MC4R Gene Variants and Dietary Habits in the Development of Obesity among Adolescents
    Ahmad Faraz, Muhammad Saqib Khan, Tipu Sultan Haider, Hafsa Khalil
    Innovative Research in Applied, Biological and Chemical Sciences.2025; 3(1): 59.     CrossRef
  • The interplay between nutrigenomics and low-carbohydrate ketogenic diets in personalized healthcare
    Yousef M. Almoghrabi, Basmah M. Eldakhakhny, Abdulhadi I. Bima, Hussein Sakr, Ghada M. A. Ajabnoor, Hoda M. Gad, Fatma Azzahraa H. Mohammad, Salma A. Elsamanoudy, Akram Z. Awan, Ayman Z. Elsamanoudy
    Frontiers in Nutrition.2025;[Epub]     CrossRef
  • Glaucoma and dietary links: insights from high-salt intake, the Mediterranean diet, and specific nutrients
    Yuqi Yang, Hongyan Zhou, Zhang Hong
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Effect of anthocyanins on metabolic syndrome through interacting with gut microbiota
    Lanlan Du, Xiaoqin Ding, Yuwen Tian, Jian Chen, Weilin Li
    Pharmacological Research.2024; 210: 107511.     CrossRef
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  • 8 Crossref