Exercise, especially when prolonged or highly intense, can temporarily increase inflammation in both trained and untrained individuals. C-reactive protein (CRP) is an established biomarker of inflammation. However, clinical trials assessing the impact of fish oil supplementation on CRP levels in trained individuals have yielded inconsistent and often contradictory results. The main
objective
of this study was to conduct a systematic review of clinical trials exploring the effects of fish oil supplementation on CRP levels among trained individuals. We performed structured searches on the PubMed, Scopus, and ISI Web of Science databases for articles published from the earliest available date until September 2023. Of the 385 articles found and screened, three clinical trials met our criteria for inclusion in this review. The results suggested that fish oil supplementation may help prevent spikes in CRP levels after exercise. However, only one of the three studies produced statistically significant findings. The differences in statistical significance among these studies could be due to variations in the study design, sample populations, dosages, and duration of supplementation. In summary, this systematic review provides evidence that fish oil supplementation can reduce circulating CRP levels in trained individuals. Additional studies with long-term follow-up and larger sample sizes are needed to investigate this effect further.
Numerous studies have indicated that low levels of serum adiponectin are linked with the development of various chronic diseases. While some recent research has suggested that soy has a positive impact on serum adiponectin levels, the results are inconsistent. Therefore, we aim to conduct a thorough systematic review and meta-analysis of randomized controlled trials (RCTs) that investigate the effects of soy on serum adiponectin levels in adults. The search was conducted until March 2024 on PubMed, Scopus, Web of Science, and Cochrane Library databases to identify RCTs that studied the effects of soy supplementation on serum adiponectin levels. A random-effects model was used to pool the weighted mean differences (WMDs). Ten and nine RCTs were selected for the systematic review and meta-analysis, respectively. After analyzing data from 9 eligible RCTs, it was found that soy supplementation did not significantly impact the concentrations of adiponectin (WMD = −0.24 μg/mL; 95% confidence interval, −1.56 to 1.09; p = 0.72). However, there was significant heterogeneity between the studies (I2 = 89.8%, p < 0.001). Sensitivity analysis showed that overall estimates were not affected by the elimination of any study. We did not observe any evidence regarding publication bias. In conclusion, soy supplementation did not have a significant effect on adiponectin levels in adults. However, further RCTs are needed with longer intervention duration, higher doses, and studies conducted in different countries.
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Colorectal cancer (CRC) is one of the major reasons of mortality in the worldwide. There is clear evidence that some amino acids such as arginine can improve CRC and its complications. Hence, in this systematic review we evaluated the association between arginine intake and CRC improvement. We searched the PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar databases by using proper keywords to find the relevant literatures, published to March 2019. Nine human studies of 523 screened articles were included in present systematic review. The majority of studies have found a positive association between consumption of arginine and CRC improvement. Increased inducible nitric oxide (NO) synthase expression and subsequently increasing the NO concentration in the tumor and/or serum, after arginine intake may be responsible for these protective effects. Also, arginine consumption may reduce cell proliferation in CRC and it can enhance immune function after remove the tumor. Although the benefits of arginine consumption in CRC patients were reported in previous trials, the finding need replication in well-designed studies before final conclusion.
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