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"Cain C. T. Clark"

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"Cain C. T. Clark"

Original Articles
[English]
The Association Between Dietary Energy Density and Musculoskeletal Pain in Adult Men and Women
Niki Bahrampour, Niloufar Rasaei, Fatemeh Gholami, Cain C. T. Clark
Clin Nutr Res 2022;11(2):110-119.   Published online April 26, 2022
DOI: https://doi.org/10.7762/cnr.2022.11.2.110

Musculoskeletal pains (MPs), defined as persistent or recurrent pain, is a complex health problem. High overall calorie and fat intake have been related to obesity and MPs. Dietary energy density (DED), defined as energy content of food and beverages (in kcal) per unit total weight, has been associated with chronic muscle, cartilage, bone damage and pain. Thus, the purpose of this study is to investigate the association between DED and MPs in adult men and women. A total of 175 men and women (> 18 years) with MP participated in the study. A validated short form physical activity (PA) questionnaire, demographic, and McGill Pain Questionnaire were used. Anthropometric measurements were evaluated via standard protocols. Furthermore, a seven-day 24-hour recall of diet was used to determine the dietary intake. Total DED was calculated and divided into quartiles. Linear regression was used to discern the association between DED and MPs in adults. Participants assigned in the highest category of DED were characterized by lower intake of potassium, magnesium, vitamin C, folate, and fiber. However, results showed displayed higher intake of sodium, vitamin E, vitamin B3, fat, protein, cholesterol, saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids (p < 0.001). Finally, after adjustment for confounders such as age, gender, PA, body mass index, waist circumference, education, job, marital status, history of some chronic diseases and vitamin C supplementation, a significant positive association was detected between DED and pain intensity. There was no significant association between DED and pain frequency in all models.

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  • iNOS Mediates High-Fat Diet-Associated Aggravation of Complete Freund’s Adjuvant-Induced Inflammatory Pain
    Elmo Wing-Yiu Lee, Lin Wang, Jessica Ai-Jia Liu, Chi-Wai Cheung
    International Journal of Molecular Sciences.2025; 26(11): 5422.     CrossRef
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[English]
The Effect of Walnut (Juglans regia) Leaf Extract on Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Atieh Mirzababaei, Mojtaba Daneshvar, Faezeh Abaj, Elnaz Daneshzad, Dorsa Hosseininasab, Cain C. T. Clark, Khadijeh Mirzaei
Clin Nutr Res 2022;11(2):120-132.   Published online April 25, 2022
DOI: https://doi.org/10.7762/cnr.2022.11.2.120

Numerous clinical trials have examined the beneficial effects of Juglans regia leaf extract (JRLE) in patients with type 2 diabetes mellitus (T2DM); however, the results of these studies are inconsistent. Therefore, we conducted the current systematic review and meta-analysis to evaluate the effect of JRLE on glycemic control and lipid profile in T2DM patients. We searched online databases including PubMed, Scopus, EMBASE, and Web of Science for randomized controlled clinical trials that examined the effect of JRLE on glycemic and lipid indices in T2DM patients. Data were pooled using both fixed and random-effect models and weighted mean difference (WMD) was considered as the overall effect size. Of the total records, 4 eligible studies, with a total sample size of 195 subjects, were included. The meta-analysis revealed that JRLE supplementation significantly reduces fasting blood glucose (WMD, −18.04; 95% confidence interval [CI], −32.88 mg/dL, −3.21 mg/dL; p = 0.017) and significantly increases fasting insulin level (WMD, 1.93; 95% CI, 0.40 U/L, 3.45 U/L; p = 0.014). Although the overall effect of JRLE supplementation on hemoglobin A1c was not significant, a significant reduction was seen in studies with an intervention duration of > 8 weeks (WMD, −0.64; 95% CI, −1.16%, −0.11%; p = 0.018). Moreover, we also found no significant change in lipid parameters. Our findings revealed a beneficial effect of JRLE supplementation on glycemic indices in T2DM patients, but no significant improvement was found for lipid profile parameters.

Citations

Citations to this article as recorded by  
  • Harnessing the Potential of Walnut Leaves from Nerpio: Unveiling Extraction Techniques and Bioactivity Through Caenorhabditis elegans Studies
    Amel Hamdi, Miguel Angel Córdoba-Rojano, Jose Manuel Monje-Moreno, Elisa Guillén-Izquierdo, Rocío Rodríguez-Arcos, Ana Jiménez-Araujo, Manuel Jesús Muñoz-Ruiz, Rafael Guillén-Bejarano
    Foods.2025; 14(6): 1048.     CrossRef
  • Investigation of Protective Effect of Hydroalcoholic Extract of Walnut Tree Leaves (Juglans regia) on Gentamicin-Induced Nephrotoxicity in Male Wistar Rats
    Zahra Meraati, Mahsa Ale-Ebrahim, Pejman Mortazavi, Ali Chitgar, Saeed Aghebat_Bekheir
    Natural Product Communications.2025;[Epub]     CrossRef
  • Comparative Study of Different Walnut (Juglans regia L.) Varieties Based on Their Nutritional Values
    Lilla Szalóki-Dorkó, Pradeep Kumar, Dóra Székely, György Végvári, Gitta Ficzek, Gergely Simon, László Abrankó, Judit Tormási, Géza Bujdosó, Mónika Máté
    Plants.2024; 13(15): 2097.     CrossRef
  • A Property-Response Approach to Evaluate Acute Toxicity Profile and Pharmacological Quality of Hydro-Alcoholic Extract of Walnut Root Bark Juglans Regia Linn. in Streptozotocin-Induced Diabetic Mode
    Mohamed Akram Melakhessou, Imene Becheker, Salah Eddine Marref, Mohamed Sabri Bensaad, Amal Alyamani, Rokayya Sami, Mahmoud Helal, Abeer M. Aljaadi, Rasha A. Al-Eisa, Naseh A. Algehainy, Faisal H. Altemani
    Journal of Biobased Materials and Bioenergy.2023; 17(4): 451.     CrossRef
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[English]
Association of Nutrient Patterns with Metabolic Syndrome and Its Components in Iranian Adults
Zahra Akbarzade, Mohammad Reza Amini, Farhang Djafari, Habib Yarizadeh, Fatemeh Mohtashaminia, Maryam Majdi, Elham Bazshahi, Kurosh Djafarian, Cain C. T. Clark, Sakineh Shab-Bidar
Clin Nutr Res 2020;9(4):318-331.   Published online October 30, 2020
DOI: https://doi.org/10.7762/cnr.2020.9.4.318

We aimed to examine the association between nutrient patterns and metabolic syndrome (MetS) in Iranian adults. In a cross-sectional study of 850 self-certified healthy women and men aged 20–59 years old, dietary data were assessed using three 24-hour recall. Anthropometric measures were done and blood samples were collected to measure serum fasting serum glucose and lipid profile. The MetS was defined using the International Diabetes Federation. Major nutrient patterns were identified using principle competent analysis. In the first nutrient pattern, the individuals in the fifth quintile had a higher intake of vitamins B1, B2, B3, B5, B6, B12, zinc, iron, saturated fatty acids (SFAs), and protein. In the second nutrient pattern, individuals in the first quintile had lower consumption of zinc, SFAs, vitamin E, α-tocopherol, oleic acid, polyunsaturated fatty acids, β-carotene, linolenic acid, and monounsaturated fatty acids, compared to the fifth quintile. Furthermore, in the third nutrient pattern, the individuals in the fifth quintile had a higher intake of potassium, magnesium, phosphorous, calcium, protein, carbohydrate, vitamin C, and folate compared to other quintiles. We identified the second pattern had an indirect association with systolic and diastolic blood pressure, triglycerides, fasting blood sugar (p < 0.001 for all), and total cholesterol (p = 0.04) when it was controlled for body weight. Our findings showed that nutrient patterns may have an association with MetS components with mediating body weight.

Citations

Citations to this article as recorded by  
  • Association between oxidative balance score and risk of postpartum depression in Iranian women: a prospective cohort study
    Razieh Tabaeifard, Sara Hashempour, Maryam Karim Dehnavi, Maryam Mofidi Nejad, Noushin Omid, Mehdi Karimi, Leila Azadbakht
    Scientific Reports.2025;[Epub]     CrossRef
  • Patterns of nutrients intake in relation to depression, anxiety, and psychological distress among Iranian university employees: a cross-sectional study
    Sanaz Benisi-Kohansal, Shervin Kazeminejad, Keyhan Lotfi, Mohammad Reza Monazzam, Hossein Imani, Ahmad Esmaillzadeh
    Journal of Health, Population and Nutrition.2025;[Epub]     CrossRef
  • Longer sitting times and bulk amounts of rice intake are associated with the increased risks of metabolic dysfunction-associated fatty liver diseases (MAFLD): A case-control study
    Shahinul Alam, Mahbuba Kawser, Saif Uddin Nisar Ahmed, Md Mahabubul Alam, Md Saiful Islam, Shayla Nasrin
    Clinical Nutrition Open Science.2024; 58: 275.     CrossRef
  • Determining the effective factors in predicting diet adherence using an intelligent model
    Hediye Mousavi, Majid Karandish, Amir Jamshidnezhad, Ali Mohammad Hadianfard
    Scientific Reports.2022;[Epub]     CrossRef
  • Association of the dietary phytochemical index with general and central obesity in a sample of Iranian adults
    Elaheh Asgari, Ahmad Jayedi, Fatemeh Dehghani Firouzabadi, Zahra Noruzi, Mena Farazi, Kurosh Djafarian, Sakineh Shab-Bidar
    Journal of Functional Foods.2021; 83: 104546.     CrossRef
  • Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review
    Mihnea-Alexandru Găman, Elena-Codruța Dobrică, Matei-Alexandru Cozma, Ninel-Iacobus Antonie, Ana Maria Alexandra Stănescu, Amelia Maria Găman, Camelia Cristina Diaconu
    Nutrients.2021; 13(5): 1411.     CrossRef
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[English]
The Association between Dietary Antioxidant Quality Score and Cardiorespiratory Fitness in Iranian Adults: a Cross-Sectional Study
Hossein Shahinfar, Mahshid Shahavandi, Aliyu Tijani Jibril, Kurosh Djafarian, Cain C. T. Clark, Sakineh Shab-Bidar
Clin Nutr Res 2020;9(3):171-181.   Published online July 21, 2020
DOI: https://doi.org/10.7762/cnr.2020.9.3.171

The association between dietary antioxidant quality score (DAQS) and cardiovascular risk factors such as low cardiovascular fitness (CRF) and elevated blood pressure (BP) has rarely been investigated. To investigate the association between DAQS, CRF, and BP. This cross-sectional study was conducted on 270 adult subjects living in Tehran, Iran. Dietary intake was evaluated using a validated food frequency questionnaire. The DAQS was calculated using antioxidant-nutrient intake. Socio-economic status, anthropometric measures, and BP were recorded by a trained interviewer, using standard methods. A significant increase was found in maximal oxygen uptake (p value = 0.01) across tertiles of DAQS. After adjusting for confounders, the association remained unchanged (p value = 0.02). Participants in the highest tertile of DAQS had higher systolic BP (SBP) (p value = 0.01) and diastolic BP (DBP) (p value = 0.03), although adjustment for confounding factors attenuated the results (p value = 0.3 for DBP and p value = 0.6 for SBP). Our results revealed that higher DAQS is associated with better CRF in Iranian adults. Further studies are needed to establish the veracity of our results.

Citations

Citations to this article as recorded by  
  • The interaction of the dietary antioxidant status indices and paraoxonase1 rs662 polymorphism on the lipid profile and severity of coronary artery stenosis in adults undergoing coronary angiography
    Mina Darand, Mohammad Haji Aghajani, Vahid Arabi, Fatemeh Sadat Mirjalili, Matin Mohyadini, Amin Salehi-Abargouei
    Journal of Functional Foods.2025; 131: 106935.     CrossRef
  • Association Between Dietary Antioxidant Quality Score (DAQS) and All-Cause Mortality in Hypertensive Adults: A Retrospective Cohort Study from the NHANES Database
    Jiahong Wang, Jinwen Wang, Shuhong Wang, Jing Ma, Liang Yin, Yijie Guo, Xiangchen Li
    Biological Trace Element Research.2024; 202(11): 4978.     CrossRef
  • Association between dietary antioxidant capacity and type 2 diabetes mellitus in Chinese adults: a population-based cross-sectional study
    Xiaoxia Li, Yixuan Xue, Yadi Zhang, Qingan Wang, Jiangwei Qiu, Jiaxing Zhang, Chan Yang, Yi Zhao, Yuhong Zhang
    Nutrition & Metabolism.2024;[Epub]     CrossRef
  • Association between dietary antioxidant quality score and periodontitis: A cross-sectional study
    Tianyi Zhang, Yanhong Hao, Rui Zhang, Shiyao Lin
    Journal of Dental Sciences.2024; 19(1): 92.     CrossRef
  • Association of dietary antioxidant indices with kidney function indicators in patients with type 2 diabetes: a cross-sectional study
    Noushin Omid, Ensieh Nasli Esfahani, Razieh Tabaeifard, Mohsen Montazer, Leila Azadbakht
    Scientific Reports.2024;[Epub]     CrossRef
  • Relationship between dietary intake components and hepatic fibrosis in those with obesity before and 1 year after bariatric surgery
    Katherine J.P. Schwenger, Yasaman Ghorbani, Kuorosh Rezaei, Sandra E. Fischer, Timothy D. Jackson, Allan Okrainec, Johane P. Allard
    Nutrition.2023; 114: 112095.     CrossRef
  • Dietary Antioxidant Quality Score (DAQS), serum lipids, markers of glucose homeostasis, blood pressure and anthropometric features among apparently metabolically healthy obese adults in two metropolises of Iran (Tabriz and Tehran): a cross-sectional study
    Negin Nikrad, Amir Shakarami, Ayda Zahiri Tousi, Mahdieh Abbasalizad Farhangi, Abnoos Mokhtari Ardekani, Faria Jafarzadeh
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • Association between dietary antioxidant quality score and severity of coronavirus infection: a case–control study
    Mobina Aghajani, Alexei Wong, Mehdi Azimi, Shadmehr Mirdar Harijani
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Cross sectional determinants of VO2 max in free living Iranians: Potential role of metabolic syndrome components and vitamin D status
    Nadia Babaei, Samira Davarzani, Sheida Motlagh, Mojdeh Ebaditabar, Nasim Saeidifard, Gholamreza Mohammadi-Farsani, Kurosh Djafarian, Mario J. Soares, Sakineh Shab-Bidar
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(7): 102553.     CrossRef
  • The association between dietary inflammatory index, dietary antioxidant index, and mental health in adolescent girls: an analytical study
    Parvin Dehghan, Marzieh Nejati, Farhad Vahid, Amir Almasi-Hashiani, Sevda Saleh-Ghadimi, Reza Parsi, Hamed Jafari-Vayghan, Nitin Shivappa, James R. Hébert
    BMC Public Health.2022;[Epub]     CrossRef
  • The lack of association between dietary antioxidant quality score with handgrip strength and handgrip endurance amongst Tehranian adults: A cross‐sectional study from a Middle East country
    Hossein Shahinfar, Farhang Djafari, Mahshid Shahavandi, Yahya Jalilpiran, Samira Davarzani, Cain C. T. Clark, Kurosh Djafarian, Sakineh Shab‐Bidar
    International Journal of Clinical Practice.2021;[Epub]     CrossRef
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[English]
Association of Dietary Patterns with Visceral Adiposity, Lipid Accumulation Product, and Triglyceride-Glucose Index in Iranian Adults
Mohammad Reza Amini, Hossein Shahinfar, Nadia Babaei, Samira Davarzani, Mojdeh Ebaditabar, Kurosh Djafarian, Cain C. T. Clark, Sakineh Shab-Bidar
Clin Nutr Res 2020;9(2):145-156.   Published online April 27, 2020
DOI: https://doi.org/10.7762/cnr.2020.9.2.145

In the present study, we sought to examine the association between dietary patterns (DPs) and visceral adiposity, lipid accumulation product (LAP), and triglyceride-glucose index. This cross-sectional study was conducted on adults aged between 18–45 years old who lived in Tehran, Iran, between February 2017 and December 2018 (n = 270). DPs were derived using principal component analysis. We used analysis of variance to examine differences in continues variables across tertiles of major DPs. Subsequently, for the modeling of these relationships, and also considering the possible effect of the confounding factors, multivariate regression was used. Three DPs were identified: healthy pattern, mixed pattern, and western pattern, respectively. Compared with individuals in the lowest category of mixed pattern, those in the highest category had lower fasting blood sugar (96.26 ± 11.57 vs. 101 ± 28.66, p = 0.01). A significant association was found between healthy pattern, after adjustment for potential confounders, and odds of LAP; such that individuals in the top category of healthy pattern score were 71% less likely to have a high LAP compared with those in the lowest category (odds ratio, 0.29; 95% confidence interval, 0.10–0.81). We found that adherence to a healthy DP was associated with decreased LAP. To confirm the veracity of these findings, more studies should be conducted.

Citations

Citations to this article as recorded by  
  • Interaction of genetic risk score (GRS) and Plant-Based diet on atherogenic factors and body fat distribution indices among women with overweight and obesity: a cross-sectional study
    Mahya Mehri Hajmir, Atieh Mirzababaei, Faezeh Abaj, Yasaman Aali, Mahsa Samadi, Khadijeh Mirzaei
    Scientific Reports.2025;[Epub]     CrossRef
  • The Effect of a Program to Improve Adherence to the Mediterranean Diet on Cardiometabolic Parameters in 7034 Spanish Workers
    Ignacio Ramírez Gallegos, Marta Marina Arroyo, Ángel Arturo López-González, Maria Teófila Vicente-Herrero, Daniela Vallejos, Tomás Sastre-Alzamora, José Ignacio Ramírez-Manent
    Nutrients.2024; 16(7): 1082.     CrossRef
  • Association of low-carbohydrate diet score and carbohydrate quality with visceral adiposity and lipid accumulation product
    Fatemeh Gholami, Fahime Martami, Parivash Ghorbaninezhad, Amin Mirrafiei, Mojdeh Ebaditabar, Samira Davarzani, Nadia Babaei, Kurosh Djafarian, Sakineh Shab-Bidar
    British Journal of Nutrition.2023; 129(5): 843.     CrossRef
  • Meal-specific dietary patterns and biomarkers of insulin resistance in a sample of Iranian adults: a cross-sectional study
    Azadeh Lesani, Ahmad Jayedi, Mehrdad Karimi, Kurosh Djafarian, Bahareh Barkhidarian, Zahra Akbarzade, Sakineh Shab-Bidar
    Scientific Reports.2023;[Epub]     CrossRef
  • The association between dietary pattern and visceral adiposity index, triglyceride-glucose index, inflammation, and body composition among Iranian overweight and obese women
    Fatemeh Gholami, Zahra Karimi, Mahsa Samadi, Neda Sovied, Mir Saeid Yekaninejad, Seyed Ali Keshavarz, Gholamali Javdan, Niki Bahrampour, Alexei Wong, Cain C. T. Clark, Khadijeh Mirzaei
    Scientific Reports.2023;[Epub]     CrossRef
  • Association of major dietary patterns with resting metabolic rate and body fatness in middle-aged men and women: Results from a cross-sectional study
    Hossein Shahinfar, Nastaran Payandeh, Mojdeh Ebaditabar, Nadia Babaei, Samira Davarzani, Kurosh Djafarian, Sakineh Shab-Bidar
    Nutrition and Health.2023; 29(1): 139.     CrossRef
  • Correlation between Lipid Accumulation Product with Fasting Blood Glucose and CRP in Obese Females
    Natra Dias Surohadi, Dwi Retnoningrum, Meita Hendrianingtyas, Etika Ratna Noer, Ahmad Syauqi
    INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY.2023; 29(1): 11.     CrossRef
  • Population food intake clusters and cardiovascular disease incidence: a Bayesian quantifying of a prospective population-based cohort study in a low and middle-income country
    Reyhaneh Rikhtehgaran, Khadijeh Shamsi, Elnaz Mojoudi Renani, Arman Arab, Fatemeh Nouri, Noushin Mohammadifard, Hamid Reza Marateb, Marjan Mansourian, Nizal Sarrafzadegan
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Interaction analysis of lipid accumulation product and family history of diabetes on impaired fasting glucose and diabetes risk in population with normotension in Eastern China: a community-based cross-sectional survey
    Li Shu, Yingying Zhao, Yanqi Shen, Linlin Jia, Jiaye Zhang
    Archives of Public Health.2022;[Epub]     CrossRef
  • Dietary insulin index and insulin load in relation to hypertriglyceridemic waist phenotype and low brain derived neurotrophic factor in adults
    Zahra Hajhashemy, Keyhan Lotfi, Farnaz Shahdadian, Parisa Rouhani, Zahra Heidari, Parvane Saneei
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Association of Vitamin D status with Visceral Adiposity Index and Lipid Accumulation Product Index among a Group of Iranian People
    Elham Bazshahi, Sanaz Pourreza, Mahtab Ghanbari, Zeinab Khademi, Mohammad Reza Amini, Kurosh Djafarian, Sakineh Shab-Bidar
    Clinical Nutrition Research.2021; 10(2): 150.     CrossRef
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  • 11 Crossref