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Original Article

Effects of Soy Flour Fortified Bread Consumption on Cardiovascular Risk Factors According to APOE Genotypes in Overweight and Obese Adult Women: A Cross-over Randomized Controlled Clinical Trial

Elham Sharifi-Zahabi1, Mohammad H Entezari1, Mohammad R Maracy2
Clinical Nutrition Research 2015;4(4):225-234.
Published online: October 31, 2015

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Corresponding author: Mohammad Hasan Entezari. Address: Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran. Tel: +98-311-7922775, Fax: +98-311-6682509, entezari@hlth.mui.ac.ir
• Received: July 8, 2015   • Revised: September 29, 2015   • Accepted: October 3, 2015

© 2015 The Korean Society of Clinical Nutrition

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of Soy Flour Fortified Bread Consumption on Cardiovascular Risk Factors According to APOE Genotypes in Overweight and Obese Adult Women: A Cross-over Randomized Controlled Clinical Trial
Clin Nutr Res. 2015;4(4):225-234.   Published online October 31, 2015
DOI: https://doi.org/10.7762/cnr.2015.4.4.225
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Effects of Soy Flour Fortified Bread Consumption on Cardiovascular Risk Factors According to APOE Genotypes in Overweight and Obese Adult Women: A Cross-over Randomized Controlled Clinical Trial
Clin Nutr Res. 2015;4(4):225-234.   Published online October 31, 2015
DOI: https://doi.org/10.7762/cnr.2015.4.4.225
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Effects of Soy Flour Fortified Bread Consumption on Cardiovascular Risk Factors According to APOE Genotypes in Overweight and Obese Adult Women: A Cross-over Randomized Controlled Clinical Trial
Image Image
Figure 1 The enrollment of study participants.
Figure 2 Study diagram. Group 1: treatment from soy bread diet to control diet (regular diet), Group 2: treatment from control diet to soy bread diet.

Figure 1

Figure 2

Effects of Soy Flour Fortified Bread Consumption on Cardiovascular Risk Factors According to APOE Genotypes in Overweight and Obese Adult Women: A Cross-over Randomized Controlled Clinical Trial
Table 1 Approximate nutrient composition of soy flour fortified bread
Table 2 Energy and nutrient intake of subjects during the study*

*All values are shown in mean ± SD; †Soy bread diet: all subjects in this group received a weight loss diet and were also asked to replace 120 g of their usual bread intake with identical amount of soy flour fortified bread; ‡Regular diet: all participant were on their regular diet; subjects were asked not to consume soy products; §Differences of variable between two groups (soy bread - regular diet); ∥p values for differences between two groups (paired t-test).

Table 3 Effect of soy bread and regular diet on anthropometric values*

HC: hip circumference, WHR: waist to hip ratio, SBD: soy bread diet, RD: regular diet.

*All values are shown in mean ± SD; †Mean change differences of variable = mean differences in soy bread diet-mean differences in regular diet; ‡p values for mean change differences between two groups (Paired t-test); §All subjects in this group received a weight loss diet and were also asked to replace 120 g of their usual bread intake with identical amount of soy bread; ∥All participant were on their regular diet; subjects were asked not to consume soy products.

Table 4 Effect of soy bread and regular diet on serum lipids and blood pressure*

TC: total cholesterol, TG: triglycerides, LDL-C: low density lipoprotein cholesterol, HDL-C: high density lipoprotein cholesterol, SBP: systolic blood pressure, DBP: diastolic blood pressure, SBD: soy bread diet, RD: regular diet.

*All values are showed in mean ± SD; †Mean change differences of variable = mean differences in soy bread diet - mean differences in regular diet; ‡p values for mean change differences between two groups (Paired t-test); §All subjects in this group received a weight loss diet and were also asked to replace 120 g of their usual bread intake with identical amount of soy bread; ∥All participant were on their regular diet; subjects were asked not to consume soy products. Marginally significant difference for DBP between SBD and RD (p = 0.06).

Table 5 Differences of variables between soy bread and regular diet in E2 and E3 genotype groups*, †

WC: waist circumference, HC: hip circumference, WHR: waist to hip ratio, DBP: diastolic blood pressure, SBP: systolic blood pressure, TC: total cholesterol, TG: triglycerides, LDL-C: low density lipoprotein cholesterol, HDL-C: high density lipoprotein cholesterol.

*Values are showed in mean ± SD; †Mean change differences of variable = mean differences in soy bread diet - mean differences in regular diet.

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