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Case Report

Nutrition Therapy for Mitochondrial Neurogastrointestinal Encephalopathy with Homozygous Mutation of the TYMP Gene

Jing Wang1, Wei Chen2, Fang Wang3, Dong Wu4, Jiaming Qian4, Junren Kang2, Hailong Li2, Enling Ma2
Clinical Nutrition Research 2015;4(2):132-136.
Published online: January 16, 2015

1Department of Clinical Nutrition, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.

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Corresponding author: Wei Chen. Address: Department of Parenteral and Enteral, Peking Union Medical School Hospital, 1#Shuaifuyuan, Dongcheng District, Beijing 100730, China. Tel +86-139-1100-6820, Fax +86-010-6915-4095, txchenwei@sina.com
• Received: October 10, 2014   • Revised: November 24, 2014   • Accepted: November 29, 2014

© 2015 The Korean Society of Clinical Nutrition

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nutrition Therapy for Mitochondrial Neurogastrointestinal Encephalopathy with Homozygous Mutation of the TYMP Gene
Clin Nutr Res. 2015;4(2):132-136.   Published online January 16, 2015
DOI: https://doi.org/10.7762/cnr.2015.4.2.132
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Nutrition Therapy for Mitochondrial Neurogastrointestinal Encephalopathy with Homozygous Mutation of the TYMP Gene
Clin Nutr Res. 2015;4(2):132-136.   Published online January 16, 2015
DOI: https://doi.org/10.7762/cnr.2015.4.2.132
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Nutrition Therapy for Mitochondrial Neurogastrointestinal Encephalopathy with Homozygous Mutation of the TYMP Gene
Image Image
Figure 1 Abdominal and pelvic computed tomography scans. (A): The angle between the abdominal aorta and superior mesenteric artery (short white arrow) was significantly smaller. (A) and (B): The position of the stomach was significantly lower. The stomach and intestines were significantly dilated with large quantities of liquid. (C): The gastrointestinal wall was uniformly thick with homogeneous enhancement (long white arrows). (D): The density of the whole liver was significantly reduced, and the volume was elevated.
Figure 2 Cranial MRI showing cerebral white matter changes. (A): A T1-weighted image showing bilateral cerebral white matter fibers (long black arrows) and the bilateral thalamus (short black arrows) with diffuse, symmetrical, low-signal intensity. (B) and (C): T2-weighted (B) and fluid-attenuated inversion recovery images (C) showing bilateral cerebral white matter fibers(long black arrows) and the bilateral thalamus(short black arrows) with diffuse, symmetrical, high-signal intensity. (D): No significant diffusion is observed on the diffusion-weighted.

Figure 1

Figure 2

Nutrition Therapy for Mitochondrial Neurogastrointestinal Encephalopathy with Homozygous Mutation of the TYMP Gene
Table 1 Biochemical test results and nutrition therapy of the patient

TG: triglyceride, ALT: alanine aminotransferase, NPC: daily intake of non-protein calories, Fat (g/kg): grams of fat intake per kilogram of body weight, Glucose (g/kg): grams of glucose intake per kilogram of body weight, Amino acids (g/kg): grams of amino acids intake per kilogram of body weight.

Table 1

CNR : Clinical Nutrition Research

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