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Original Article

Risk of Osteoporotic Fractures Among Obese Women Based on Body Mass Index and Waist Circumference: A Nationwide Cohort in South Korea

Gyeongsil Lee1orcid, Seulggie Choi2orcid, Yoosun Cho3orcid, Sang Min Park1,2orcid
Clinical Nutrition Research 2022;11(1):32-41.
Published online: February 7, 2022

1Department of Family Medicine, Seoul National University Hospital, Seoul 03080, Korea.

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Correspondence to Sang Min Park. Department of Family Medicine and Biomedical Sciences, College of Medicine, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea. smpark.snuh@gmail.com
• Received: December 28, 2021   • Revised: February 2, 2022   • Accepted: February 6, 2022

Copyright © 2022. The Korean Society of Clinical Nutrition

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • We evaluated the association between obesity status by body mass index (BMI) or waist circumference (WC) and osteoporotic fracture risk. We collected data of 143,673 women with a mean age of 58.5 years without history of osteoporotic fracture from the Korean National Health Insurance Service Cohort. Participants were divided into four groups according to obesity by BMI and WC, normal BMI/WC (BMI 18.5–24.9 kg/m2 and WC < 85 cm, reference), obese BMI/normal WC (BMI ≥ 25 kg/m2 and WC < 85 cm), normal BMI/obese WC (BMI < 25 kg/m2 and WC ≥ 85 cm), and obese BMI/WC (BMI ≥ 25 kg/m2 and WC < 85cm). Cox proportional hazards regression analyses were performed to obtain hazard ratios (HRs) with 95% confidence intervals (CIs) for the subsequent median 6.0 years, which were adjusted for age, socioeconomic status, lifestyle, morbidity index, and osteoporosis medication. Compared with the normal group, normal BMI/obese WC was associated with a higher osteoporotic fracture risk after multivariable adjustment (HRs [95% CI], 1.13 [1.05–1.21]), and obese BMI/normal WC was associated with a lower osteoporotic fracture risk (0.89 [0.84–0.94]). Obese BMI/normal WC was associated with a lower risk for hip fractures (0.75 [0.57–0.99]). Obese BMI/normal WC was associated with decreased risk of osteoporotic fracture, whereas normal BMI/obese WC was associated with increased risk of osteoporotic fracture compared with the normal group among East Asian women in their late 40s or more.
  • Keywords: Osteoporotic fractures; Hip fractures; Obesity; Abdominal obesity
Obesity and osteoporosis are major causes of morbidity and mortality [1,2]. Traditionally, obesity has been defined based on a high body mass index (BMI) and has been shown to be protective against osteoporotic fractures. The underlying protective effect of obesity has been explained by a mechanical load followed by a higher bone mineral density and fat padding effect around the hip caused by aromatase activity affecting free sex-hormones [3, 4, 5, 6].
However, the protective effect of obesity on osteoporotic fractures has recently been increasingly challenged. A meta-analysis of 6 studies reported no association between BMI and the risk of vertebral fracture [7]. The Nurses’ Health Study recently reported that high BMI was related to reduced vertebral fractures, whereas high waist circumference (WC) was related to an increased risk of vertebral fractures [8]. Other studies have also reported that obesity, defined as high WC or waist-to-hip ratio (WHR), is associated with an increased risk of hip fractures [9, 10].
These conflicting results on the effect of obesity on osteoporotic fractures, depending on how obesity is defined, suggest that body composition could be an important predictor of osteoporotic fractures. Normal BMI but obese WC is relatively high fat; conversely, obese BMI but normal WC is relatively high muscle. In particular, normal weight obesity, defined as excessive body fat with normal BMI, was known to be associated with cardiovascular mortality [11]; however, the effect on the osteoporotic fractures is unclear.
There is a paucity of studies investigating the combination of BMI and WC, which can distinguish the misclassification of obesity status caused by different criteria such as BMI or WC. Therefore, we aimed to evaluate the association between obesity status, determined using BMI and WC, and the risk of osteoporotic fractures among women in their late 40s or more with median 6.0 years follow-up period to determine whether there is a discrepancy in the risk on the basis of whether obesity is defined according to BMI or WC.
Data source and study design
We retrospectively analyzed a large Korean cohort from the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) database, which is recorded between January 1, 2002 and December 31, 2015 (NHIS-2018-2-163). The Korean National Health screening is conducted biannually based on whether individuals’ birth year is even or odd. The NHIS-HEALS database includes clinical data, date of hospital visits, admissions, diagnoses, and death information. The NHIS database has been used for population-based epidemiological studies, and its validity has been recognized elsewhere [12].
Study population
NHIS-HEALS database is recorded between 2002 and 2015. Because WC measurements were started in 2008, the authors used data from 2008. Supplementary Fig. 1 shows the flow of the study population. Of 228,881 women who had undergone national health examination from 2008 to 2009, we excluded 1,196 subjects who died and 18,537 participants diagnosed with fractures defined as having one day or more hospitalization or 2 times or more physician visits within 6 months based on osteoporotic fracture diagnoses coded according to the International Classification of Disease 10th revision (ICD-10) before the index date (January 1, 2010). Because the history of prior fracture was significantly associated with an increased risk of new fractures [13], we excluded subjects who had any previous osteoporotic fracture. We also excluded 57,884 women without information on BMI or WC and 4,396 women with missing covariates. Lastly, 3,195 subjects who were underweight (BMI < 18.5 kg/m2) were excluded, and 143,673 women were included in the analysis.
All participants were followed up starting from the index date of January 1, 2010, until the date of the hospitalization for more than 2 days due to an osteoporotic fracture among vertebral, hip, humerus, and distal radius fractures, death, or December 31, 2015, whichever came first.
Exposures and covariates
Height, weight, and WC were measured by nurses trained on the NHIS examination. BMI was calculated by weight/height2 (kg/m2). Based on the Asian criteria of BMI and WC [14], the cohort was divided into 4 groups: normal (BMI 18.5–24.9 kg/m2 + WC < 85 cm), obese BMI/normal WC (BMI ≥ 25 kg/m2 + WC < 85 cm), normal BMI/obese WC (BMI 18.5–24.9 kg/m2 + WC ≥ 85 cm), and obesity by both BMI and WC (BMI ≥ 25 kg/m2 + WC ≥ 85 cm). The covariates included age, socioeconomic status, regular exercise, smoking status (never, previous, and current), alcohol habit (none, < 3, ≥ 3 times/week), bisphosphonate medication, and the Charlson Comorbidity Index (CCI) [15] which is the most commonly used comorbidity index for predicting mortality. All covariates were collected before the index date.
Main outcomes
Fractures were identified by ICD-10 codes: vertebral (S22.0 [fracture of the thoracic spine], S22.1 [multiple fractures of the thoracic spine], S32.0 [fracture of the lumbar spine], M48.4 [fatigue fracture of the vertebra] and M48.5 [collapsed vertebra, NEC]); hip (S72.0 [fracture of the femoral neck] and S72.1 [pertrochanteric fracture]); wrist (distal radius) (S52.5 [fracture of the distal radius] and S52.6 [combined fracture of the distal radius/ulna]); and humerus (S42.2 [fracture of the proximal humerus] and S42.3 [fracture of shaft of the humerus]) [16, 17, 18, 19].
The primary outcome of this study was defined as being hospitalized for one day or more or physician visits 2 times or more within 6 months of osteoporotic fractures, whichever fracture occurred earliest. In turn, when multiple fractures occurred during the observation period, only the first fracture was considered the outcome [18, 19]. The secondary outcome was osteoporotic fractures requiring hospitalization for 2 days or more, as a marker for severe fractures, whichever occurred earliest.
Statistical analysis
Continuous variables are expressed as mean (± standard deviation), and categorical variables are expressed as percentages, and they were compared between groups using the Pearson’s χ2 test. Hazard ratios (HRs) and 95% confidence intervals (CIs) for each outcome, according to the 4 groups were analyzed using the Cox proportional hazards regression analyses. The multivariable-adjusted analysis was adjusted for age, socioeconomic status, regular exercise, smoking status, drinking habit, and CCI. Because not only BMI or WC but also osteoporotic fractures are closely related to age, subgroup analyses according to different age-bands were performed: < 50, 51–60, 61–70, ≥ 71 years. The combination of BMI and WC was additionally categorized as nine groups by tertiles of BMI and WC because BMI and WC increase with age, although the reference value of obesity in BMI and WC was fixed at 25.0 kg/m2 and 85 cm, respectively. Statistical significance was set as a two-sided p value < 0.05. Data mining and analyses were conducted using SAS Enterprise Guide 7.1 (SAS Institute, Cary, NC, USA).
Ethics
This study was conducted according to the guidelines in the Declaration of Helsinki, and all procedures involving human subjects/patients were waived by the Institutional Review Board of the Seoul National University (IRB number: 1703-039-863). All participants were informed regarding the objective of the survey, and they provided consent. The NHIS database was anonymized according to strict confidentiality guidelines.
The age range of the study population of 143,673 women was 47–86 years in the index year. The median follow-up duration of the study population was 6.0 years (interquartile range, 5.995–5.995 [the same]), resulting in 818,648 person-years. During the period, 11,742 subjects’ osteoporotic fractures required treatment. The crude incidence was 14.3 per 1,000 person-years. Table 1 summarizes the baseline characteristics of the study participants. Women with normal BMI/obese WC were more likely to be older, have comorbidity, and exercise less. Table 2 shows the association of obesity status, measured using BMI and WC, with the risk of osteoporotic fractures requiring hospitalization or physician visits (primary outcome), adjusted for 2 steps as age-adjusted and multivariable-adjusted for age, income, smoking status, drinking habit, regular exercise, bisphosphonate medication, and CCI. The risk of fracture differed based on how obesity was defined using BMI or WC. The risk of osteoporotic fractures was the highest in women with normal BMI/obese WC and the lowest in women with obese BMI/normal WC. The risk of osteoporotic fracture was marginally protective in women with obesity by both BMI and WC.
Table 1

General characteristics of the study population (n = 143,673 women)

Table 1
Obesity status Normal Obese BMI/normal WC Normal BMI/obese WC Obesity by both BMI and WC
< 85 cm/18.5–24.9 kg/m2 < 85 cm/≥ 25 kg/m2 ≥ 85 cm/18.5–24.9 kg/m2 ≥ 85 cm/≥ 25 kg/m2
No. (%) 87,869 (61.2) 21,400 (14.9) 7,412 (5.2) 26,992 (18.8)
Osteoporotic fracture events 6,703 1,499 962 2,578
Age (yr) 57.3 ± 8.5 57.9 ± 8.1 64.0 ± 9.4 61.5 ± 8.8
≤ 50 (%) 25.8 21.1 8.5 11.5
51–60 (%) 44.5 46.1 31.0 38.1
61–70 (%) 19.2 23.4 31.9 31.6
≥ 71 (%) 10.5 9.4 28.7 19.0
BMI (kg/m2) 22.3 ± 1.6 26.4 ± 1.4 23.6 ± 1.1 28.0 ± 2.3
WC (cm) 74.7 ± 5.2 80.0 ± 3.4 87.7 ± 3.0 90.6 ± 5.0
Income (%)
Highest 32.3 28.1 30.9 27.9
Upper middle 28.2 30.5 29.9 31.6
Lower middle 23.3 24.4 22.2 23.6
Lowest 16.3 16.9 17.0 16.9
Smoking (%)
Never 97.9 98.1 97.5 97.7
Ever 2.1 1.9 2.5 2.3
Alcohol (%)
Never 84.3 84.0 87.8 86.3
< 3/week 13.8 13.9 10.3 11.7
≥ 3/week 1.9 2.1 1.9 2.1
Exercise (%)
None 53.0 54.1 62.1 61.4
< 3/week 31.2 29.0 24.7 24.4
≥ 3/week 15.6 16.8 13.3 14.3
CCI (%)
0 21.3 18.7 12.8 12.9
1–2 53.5 52.9 49.1 48.4
≥ 3 25.3 28.4 38.1 38.7
Bisphosphonate medication
On medication (%) 15.0 14.1 26.6 19.2
Values are presented as mean ± standard deviation not otherwise specified.
BMI, body mass index; WC, waist circumference; CCI, Charlson Comorbidity Index.
Table 2

The association of obesity status with the risk of osteoporotic fractures (primary outcome*)

Table 2
Obesity status Normal Obese BMI/normal WC Normal BMI/obese WC Obesity by both BMI and WC
< 85 cm/18.5–24.9 kg/m2 < 85 cm/≥ 25 kg/m2 ≥ 85 cm/18.5–24.9 kg/m2 ≥ 85 cm/≥ 25 kg/m2
No. of subjects 87,869 21,400 7,412 26,992
The first events
Person-year 502,604 123,027 40,730 152,286
Events, n (incidence per 1,000†) 6,703 (13.3) 1,499 (12.2) 962 (23.6) 2,578 (16.9)
Age-adjusted, HR (95% CI) Reference 0.89 (0.84–0.94) 1.15 (1.07–1.23) 0.97 (0.92–1.01)
Multivariable, HR (95% CI)‡ Reference 0.89 (0.84–0.94) 1.13 (1.05–1.21) 0.96 (0.92–1.00)
HR, hazard ratio; CI, confidence interval; BMI, body mass index; WC, waist circumference.
*The primary outcome of this study was defined as having hospitalization for one day or more or physician visits for two times or more within six months under osteoporotic fractures, whichever came the earliest. Osteoporotic fractures include vertebral (S22.0, S22.1, S32.0, M48.4, and M48.5), hip (S72.0 and S72.1), radius (S52.5 and S52.6), and humerus (S42.2 and S42.3) fractures.
†Crude incidence per 1,000 person-years.
‡Adjusted for age, income, smoking status, alcohol habit, regular exercise, bisphosphonate medication, and Charlson Comorbidity Index.
Table 3 depicts the association of obesity status with osteoporotic fractures according to age band. Among women aged over 60 years, normal BMI/obese WC was significantly associated with osteoporotic fractures. The results of an additional analysis using a combination of BMI tertile and WC tertile (total nine subgroups) are shown in Supplementary Table 1, results of which were similar to the main results as well as subgroup analysis according to age. Table 4 demonstrates the association of obesity status with sub-types of fractures, including vertebral, hip, and other fractures, requiring hospitalization or physician visits (primary outcomes) and hospitalization (secondary outcomes), respectively. Normal BMI/obese WC was associated with a higher risk of vertebral and hip fractures in both definitions of outcomes. Hip fractures requiring hospitalization were significantly low in obese BMI/normal WC compared with the normal group. The humerus and distal radius fractures by the primary outcome were significantly low in women with high BMI, including obese BMI/normal WC and obesity by both BMI and WC, compared with the normal group.
Table 3

Stratified analysis according to age-band for the association of obesity status with the risk of osteoporotic fractures (primary outcome*)

Table 3
Obesity status Normal Obese BMI/normal WC Normal BMI/obese WC Obesity by both BMI and WC
< 85 cm/18.5–24.9 kg/m2 < 85 cm/≥ 25 kg/m2 ≥ 85 cm/18.5–24.9 kg/m2 ≥ 85 cm/≥ 25 kg/m2
≤ 50 years
No. of subjects 22,684 4,512 630 3,092
No. of events 688 130 25 96
Multivariable HR (95% CI)† Reference 0.93 (0.77–1.13) 1.27 (0.86–1.90) 0.97 (0.78–1.21)
51–60 years
No. of subjects 39,128 9,875 2,294 10,270
No. of events 2,377 528 164 648
Multivariable HR (95% CI)† Reference 0.85 (0.77–0.94) 1.09 (0.93–1.28) 0.96 (0.88–1.05)
61–70 years
No. of subjects 16,861 5,000 2,363 8,516
No. of events 1,894 526 316 965
Multivariable HR (95% CI)† Reference 0.93 (0.85–1.03) 1.13 (1.00–1.27) 0.98 (0.91–1.06)
≥ 71 years
No. of subjects 9,196 2,013 2,125 5,114
No. of events 1,744 315 457 869
Multivariable HR (95% CI)† Reference 0.83 (0.74–0.94) 1.12 (1.01–1.25) 0.89 (0.82–0.96)
HR, hazard ratio; CI, confidence interval; BMI, body mass index; WC, waist circumference.
*The primary outcome of this study was defined as having hospitalization for one day or more or physician visits for two times or more within six months under osteoporotic fractures, whichever came the earliest. Osteoporotic fractures include vertebral (S22.0, S22.1, S32.0, M48.4, and M48.5), hip (S72.0 and S72.1), radius (S52.5 and S52.6), and humerus (S42.2 and S42.3) fractures.
†Adjusted for age, income, smoking status, alcohol habit, regular exercise, bisphosphonate medication, and Charlson Comorbidity Index.
Table 4

Subgroup analysis according to the type of osteoporotic fractures according to primary and secondary outcomes*

Table 4
Obesity status Normal Obese BMI/normal WC Normal BMI/obese WC Obesity by both BMI and WC
< 85 cm/18.5–24.9 kg/m2 < 85 cm/≥ 25 kg/m2 ≥ 85 cm/18.5–24.9 kg/m2 ≥ 85 cm/≥ 25 kg/m2
No. of subtotal subjects 87,869 21,400 7,412 26,992
Vertebral fractures
No. of events (primary outcome) 2,516 606 465 1,278
Multivariable HR (95% CI)† Reference 0.97 (0.89–1.06) 1.22 (1.11–1.35) 1.15 (1.07–1.23)
No. of events (secondary outcome) 1,904 459 359 998
Multivariable HR (95% CI)† Reference 0.98 (0.88–1.08) 1.22 (1.11–1.35) 1.15 (1.07–1.23)
Hip fractures
No. of events (primary outcome) 353 67 94 176
Multivariable HR (95% CI)† Reference 0.79 (0.61–1.02) 1.39 (1.11–1.76) 0.98 (0.82–1.18)
No. of events (secondary outcome) 339 61 92 171
Multivariable HR (95% CI)† Reference 0.75 (0.57–0.99) 1.40 (1.11–1.77) 0.99 (0.83–1.20)
Humerus & radius fractures
No. of events (primary outcome) 3,834 826 403 1,124
Multivariable HR (95% CI)† Reference 0.87 (0.80–0.93) 1.05 (0.94–1.16) 0.85 (0.79–0.91)
No. of events (secondary outcome) 1,697 403 202 551
Multivariable HR (95% CI)† Reference 0.95 (0.85–1.06) 1.14 (0.98–1.32) 0.92 (0.83–1.01)
HR, hazard ratio; CI, confidence interval; BMI, Body mass index (kg/m2); WC, waist circumference (cm)
*The primary outcome of this study was defined as having hospitalization for one day or more or physician visits for two times or more within six months under osteoporotic fractures, whichever came the earliest. The secondary outcome was osteoporotic fractures requiring hospitalization for two days or more, as a marker for severe fractures, whichever came the earliest fracture. ICD-10 codes were used to identify and classify fractures: vertebral (S22.0, S22.1, S32.0, M48.4, and M48.5), hip (S72.0 and S72.1), wrist (S52.5 and S52.6), and humerus (S42.2 and S42.3).
†Adjusted for age, income, smoking status, alcohol habit, regular exercise, bisphosphonate medication, and Charlson Comorbidity Index.
In this large nationwide cohort study of 143,673 women in their late 40s or more, the discrepancy in obesity status, measured using BMI and WC, was associated with different risks of osteoporotic fractures that required inpatient treatment. Compared with normal BMI and WC, normal BMI/obese WC was associated with osteoporotic fractures; however, obese BMI/normal WC was related to a reduced risk of osteoporotic fractures. This protective effect of obese BMI/normal WC on the osteoporotic fractures was more prominent in older women. To our knowledge, this is the first study to use a combination of BMI and WC to determine obesity status. The combined use of BMI and WC reduced the likelihood of misclassification of obesity status, which is common when the two measurements are used in isolation.
The results of this study are similar to those of recent studies, although none of the studies considered BMI and WC at the same time. The Nurses’ Health Study considered both BMI and WC as obesity surrogate markers, although not in combination. When 54,934 female nurses aged between 30 and 55 years were followed for 12 years, women with WC < 71.0 cm were at a higher risk of self-reported vertebral fractures compared to women with WC > 108.0 cm; even after adjusting for covariates such as BMI [8]. A prospective cohort with 19,918 women aged > 60 years followed for a median of 8.1 years reported that higher WC and higher WHR were related to a higher risk of hip fractures after adjusting for BMI [9]. The Nurses’ Health Study and the Health Professionals Follow-up Study reported that abdominal obesity was associated with an increased risk of hip fracture after controlling for BMI in women [10]. We also found that isolated abdominal obesity and combined abdominal and general obesity were related to an increased risk of osteoporotic fractures.
The association between BMI and osteoporotic fractures is controversial. Early studies suggested that higher BMI was protective against osteoporotic fractures and osteoporosis [3, 4, 5]. A meta-analysis of 6 studies reported no association between BMI and the risk of vertebral fracture in women [7]. The Nurses’ Health Study recently reported that women with BMI > 32.0 kg/m2 had a lower risk of self-reported vertebral fractures than women with a BMI of 21.0–24.9 kg/m2 [8]. In this study, we found that isolated general obesity is associated with a reduced risk of osteoporotic fractures, whereas combined general and abdominal obesity reduces the risk of osteoporotic fractures.
The conflicting results on the impact of obesity on osteoporotic fractures, depending on the definition used for obesity, suggests that body composition or fat distribution is an important predictor of osteoporotic fractures. Technically, BMI is limited in the assessment of obesity because it cannot distinguish between lean muscle and fat. In this current study, we confirmed that combined BMI and WC alter the risk of osteoporotic fractures. Isolated abdominal obesity increased the risk of osteoporotic fracture risks. Women with isolated abdominal obesity have a relatively higher body fat content than similar weight women without abdominal obesity, which may be missed if obesity status is determined using BMI alone. A study that used percent body fat as a marker of obesity reported that the risk of hip fracture decreased linearly with a higher percent body fat among women [20]. We, therefore, propose that the mechanical load hypothesis on osteoporotic fractures remains relevant among individuals without abdominal obesity.
The complex association between obesity and bone can be explained by two aspects including fat and muscle. Increased adiposity secretes cytokines and adipokines, which are related to bone loss [21] and increased bone-marrow fat, which could increase the risk of fractures [22]. A biopsy study by Cohen et al. demonstrated that premenopausal women with more central adiposity had low bone quality and stiffness and markedly lower bone formation [23]. Additionally, abdominal obesity decreases osteoblast activity by altering the Wnt/β-catenin pathway [24]. A systematic review of 30 prospective cohort studies on muscle strength and incidence of falls reported that lower muscle strength increases the risk of falls [25]. Another study also reported that decreased thigh muscle owing to fatty infiltration of muscle, myosteatosis, increases the risk of hip fractures [26]. Muscle-derived growth factors, namely myokines such as insulin-like growth factor-1 (IGF-1) and basic fibroblast growth factor-2 (FGF-2) secreted from muscles, are known to regulate bone formation [27].
The results of this study should be interpreted considering the following limitations. First, because of the retrospective nature of the study, potential covariates regarded as related to osteoporotic fractures, including calcium intake, rheumatoid arthritis, and corticosteroid use, were not completely evaluated [28, 29]. To minimize the effect of confounders, we used the CCI, which is the most commonly used comorbidity index, although a less relevant measure in younger individuals. Additionally, the severity of existing osteoporosis and treatment was not considered, which was regarded as the risk factor for osteoporotic fractures, due to a lack of information on DEXA or bone mineral density in this cohort. To minimize this limitation, we used the medication information of osteoporosis, although the underestimation of osteoporosis still exists. Third, the change in height was not considered, although height loss is associated with prior fracture, which again increases the risk of new fractures [13]. To eliminate this bias, subjects who had any osteoporotic fracture events before the index year were excluded.
Despite these limitations, the 865,888 person-years of follow-up and using hard outcomes, such as fractures and not osteoporosis, and a nationally representative database were strengths associated with the current study.
In conclusion, obese BMI/normal WC was associated with decreased risk of osteoporotic fracture, whereas normal BMI/obese WC was associated with increased risk of osteoporotic fracture compared with the normal group among East Asian women in their late 40s or more. Our findings suggest that fat distribution, particularly central adiposity, rather than simple weight is an important predictor of future osteoporotic fractures requiring hospitalization among East Asian women.
NHIS-HEALS NHIS-2018-2-163 National Research Foundation of Koreahttps://doi.org/10.13039/501100003725 2017R1D1A1B03033721

Funding: This study used the NHIS-HEALS data (NHIS number: NHIS-2018-2-163). This research was supported by Basic Science Research Program through the National Research Foundation (NRF) funded by the Ministry of Education (grant No: 2017R1D1A1B03033721) in the Republic of Korea.

Conflict of Interest: The authors declare that they have no competing interests.

Author Contributions:

  • Conceptualization: Lee G, Park SM.

  • Data curation: Choi S.

  • Formal analysis: Lee G.

  • Funding acquisition: Choi S, Park SM.

  • Investigation: Lee G, Cho Y.

  • Methodology: Lee G, Choi S, Cho Y, Park SM.

  • Project administration: Lee G.

  • Resources: Park SM.

  • Software: Lee G, Park SM.

  • Supervision: Park SM.

  • Validation: Choi S.

  • Visualization: Lee G.

  • Writing – original draft: Lee G.

  • Writing - review & editing: Lee G, Choi S, Cho Y, Park SM.

Supplementary Table 1

Subgroup analysis according to age of the association of combination of BMI and WC with osteoporotic fractures*
cnr-11-32-s001.xls

Supplementary Fig. 1

Study population.
cnr-11-32-s002.ppt
  • 1. GBD 2015 Obesity Collaborators. Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, Marczak L, Mokdad AH, Moradi-Lakeh M, Naghavi M, Salama JS, Vos T, Abate KH, Abbafati C, Ahmed MB, Al-Aly Z, Alkerwi A, Al-Raddadi R, Amare AT, Amberbir A, Amegah AK, Amini E, Amrock SM, Anjana RM, Ärnlöv J, Asayesh H, Banerjee A, Barac A, Baye E, Bennett DA, Beyene AS, Biadgilign S, Biryukov S, Bjertness E, Boneya DJ, Campos-Nonato I, Carrero JJ, Cecilio P, Cercy K, Ciobanu LG, Cornaby L, Damtew SA, Dandona L, Dandona R, Dharmaratne SD, Duncan BB, Eshrati B, Esteghamati A, Feigin VL, Fernandes JC, Fürst T, Gebrehiwot TT, Gold A, Gona PN, Goto A, Habtewold TD, Hadush KT, Hafezi-Nejad N, Hay SI, Horino M, Islami F, Kamal R, Kasaeian A, Katikireddi SV, Kengne AP, Kesavachandran CN, Khader YS, Khang YH, Khubchandani J, Kim D, Kim YJ, Kinfu Y, Kosen S, Ku T, Defo BK, Kumar GA, Larson HJ, Leinsalu M, Liang X, Lim SS, Liu P, Lopez AD, Lozano R, Majeed A, Malekzadeh R, Malta DC, Mazidi M, McAlinden C, McGarvey ST, Mengistu DT, Mensah GA, Mensink GBM, Mezgebe HB, Mirrakhimov EM, Mueller UO, Noubiap JJ, Obermeyer CM, Ogbo FA, Owolabi MO, Patton GC, Pourmalek F, Qorbani M, Rafay A, Rai RK, Ranabhat CL, Reinig N, Safiri S, Salomon JA, Sanabria JR, Santos IS, Sartorius B, Sawhney M, Schmidhuber J, Schutte AE, Schmidt MI, Sepanlou SG, Shamsizadeh M, Sheikhbahaei S, Shin MJ, Shiri R, Shiue I, Roba HS, Silva DAS, Silverberg JI, Singh JA, Stranges S, Swaminathan S, Tabarés-Seisdedos R, Tadese F, Tedla BA, Tegegne BS, Terkawi AS, Thakur JS, Tonelli M, Topor-Madry R, Tyrovolas S, Ukwaja KN, Uthman OA, Vaezghasemi M, Vasankari T, Vlassov VV, Vollset SE, Weiderpass E, Werdecker A, Wesana J, Westerman R, Yano Y, Yonemoto N, Yonga G, Zaidi Z, Zenebe ZM, Zipkin B, Murray CJL. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med 2017;377:13-27.
  • 2. Kling JM, Clarke BL, Sandhu NP. Osteoporosis prevention, screening, and treatment: a review. J Womens Health (Larchmt) 2014;23:563-572.
  • 3. Rubin CT, Lanyon LE. Regulation of bone formation by applied dynamic loads. J Bone Joint Surg Am 1984;66:397-402.
  • 4. Edelstein SL, Barrett-Connor E. Relation between body size and bone mineral density in elderly men and women. Am J Epidemiol 1993;138:160-169.
  • 5. Felson DT, Zhang Y, Hannan MT, Anderson JJ. Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. J Bone Miner Res 1993;8:567-573.
  • 6. Gonnelli S, Caffarelli C, Nuti R. Obesity and fracture risk. Clin Cases Miner Bone Metab 2014;11:9-14.
  • 7. Kaze AD, Rosen HN, Paik JM. A meta-analysis of the association between body mass index and risk of vertebral fracture. Osteoporos Int 2018;29:31-39.
  • 8. Paik JM, Rosen HN, Katz JN, Rosner BA, Rimm EB, Gordon CM, Curhan GC. BMI, waist circumference, and risk of incident vertebral fracture in women. Obesity (Silver Spring) 2019;27:1513-1519.
  • 9. Søgaard AJ, Holvik K, Omsland TK, Tell GS, Dahl C, Schei B, Falch JA, Eisman JA, Meyer HE. Abdominal obesity increases the risk of hip fracture. A population-based study of 43,000 women and men aged 60-79 years followed for 8 years. Cohort of Norway. J Intern Med 2015;277:306-317.
  • 10. Meyer HE, Willett WC, Flint AJ, Feskanich D. Abdominal obesity and hip fracture: results from the Nurses’ Health Study and the Health Professionals Follow-up Study. Osteoporos Int 2016;27:2127-2136.
  • 11. Romero-Corral A, Somers VK, Sierra-Johnson J, Korenfeld Y, Boarin S, Korinek J, Jensen MD, Parati G, Lopez-Jimenez F. Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality. Eur Heart J 2010;31:737-746.
  • 12. Song SO, Jung CH, Song YD, Park CY, Kwon HS, Cha BS, Park JY, Lee KU, Ko KS, Lee BW. Background and data configuration process of a nationwide population-based study using the Korean National Health Insurance system. Diabetes Metab J 2014;38:395-403.
  • 13. Klotzbuecher CM, Ross PD, Landsman PB, Abbott TA 3rd, Berger M. Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 2000;15:721-739.
  • 14. Kim MK, Lee WY, Kang JH, Kang JH, Kim BT, Kim SM, Kim EM, Suh SH, Shin HJ, Lee KR, Lee KY, Lee SY, Lee SY, Lee SK, Lee CB, Chung S, Jeong IK, Hur KY, Kim SS, Woo JT. Committee of Clinical Practice Guidelines. Korean Society for the Study of Obesity. 2014 clinical practice guidelines for overweight and obesity in Korea. Endocrinol Metab (Seoul) 2014;29:405-409.
  • 15. de Groot V, Beckerman H, Lankhorst GJ, Bouter LM. How to measure comorbidity. a critical review of available methods. J Clin Epidemiol 2003;56:221-229.
  • 16. Korean Society for Bone and Mineral Research. Korean National Health Insurance Service. Osteoporosis and osteoporotic fracture fact sheet. Wonju: Korean National Health Insurance Service; 2014.
  • 17. Song SY, Kim Y, Park H, Kim YJ, Kang W, Kim EY. Effect of parity on bone mineral density: a systematic review and meta-analysis. Bone 2017;101:70-76.
  • 18. Sung JH, Kim K, Cho Y, Choi S, Chang J, Kim SM, Kim SR, Lee G, Son JS, Park SM. Association of air pollution with osteoporotic fracture risk among women over 50 years of age. J Bone Miner Metab 2020;38:839-847.
  • 19. Park C, Ha YC, Jang S, Jang S, Yoon HK, Lee YK. The incidence and residual lifetime risk of osteoporosis-related fractures in Korea. J Bone Miner Metab 2011;29:744-751.
  • 20. Moayyeri A, Luben RN, Wareham NJ, Khaw KT. Body fat mass is a predictor of risk of osteoporotic fractures in women but not in men: a prospective population study. J Intern Med 2012;271:472-480.
  • 21. Greco EA, Lenzi A, Migliaccio S. The obesity of bone. Ther Adv Endocrinol Metab 2015;6:273-286.
  • 22. Rosen CJ, Bouxsein ML. Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2006;2:35-43.
  • 23. Cohen A, Dempster DW, Recker RR, Lappe JM, Zhou H, Zwahlen A, Müller R, Zhao B, Guo X, Lang T, Saeed I, Liu XS, Guo XE, Cremers S, Rosen CJ, Stein EM, Nickolas TL, McMahon DJ, Young P, Shane E. Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study. J Clin Endocrinol Metab 2013;98:2562-2572.
  • 24. Wannenes F, Papa V, Greco EA, Fornari R, Marocco C, Baldari C, Di Luigi L, Emerenziani GP, Poggiogalle E, Guidetti L, Donini LM, Lenzi A, Migliaccio S. Abdominal fat and sarcopenia in women significantly alter osteoblasts homeostasis in vitro by a WNT/β-catenin dependent mechanism. Int J Endocrinol 2014;2014:278316.
  • 25. Moreland JD, Richardson JA, Goldsmith CH, Clase CM. Muscle weakness and falls in older adults: a systematic review and meta-analysis. J Am Geriatr Soc 2004;52:1121-1129.
  • 26. Lang T, Cauley JA, Tylavsky F, Bauer D, Cummings S, Harris TB; Health ABC Study. Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition study. J Bone Miner Res 2010;25:513-519.
  • 27. Hamrick MW, McNeil PL, Patterson SL. Role of muscle-derived growth factors in bone formation. J Musculoskelet Neuronal Interact 2010;10:64-70.
  • 28. Shahid S, Hashmi MU. Risk factors of osteoporosis among post-menopausal women. Prof Med J 2020;27:205-209.
  • 29. Crandall CJ, Ensrud KE. Osteoporosis screening in younger postmenopausal women. JAMA 2020;323:367-368.

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Risk of Osteoporotic Fractures Among Obese Women Based on Body Mass Index and Waist Circumference: A Nationwide Cohort in South Korea
Clin Nutr Res. 2022;11(1):32-41.   Published online February 7, 2022
DOI: https://doi.org/10.7762/cnr.2022.11.1.32
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Risk of Osteoporotic Fractures Among Obese Women Based on Body Mass Index and Waist Circumference: A Nationwide Cohort in South Korea
Clin Nutr Res. 2022;11(1):32-41.   Published online February 7, 2022
DOI: https://doi.org/10.7762/cnr.2022.11.1.32
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Risk of Osteoporotic Fractures Among Obese Women Based on Body Mass Index and Waist Circumference: A Nationwide Cohort in South Korea
Risk of Osteoporotic Fractures Among Obese Women Based on Body Mass Index and Waist Circumference: A Nationwide Cohort in South Korea
Reference0.89 (0.84–0.94)1.13 (1.05–1.21)0.96 (0.92–1.00) Reference0.93 (0.77–1.13)1.27 (0.86–1.90)0.97 (0.78–1.21)51–60 yearsNo. of subjects39,1289,8752,29410,270No. of events2,377528164648Multivariable HR (95% CI)† Reference0.85 (0.77–0.94)1.09 (0.93–1.28)0.96 (0.88–1.05)61–70 yearsNo. of subjects16,8615,0002,3638,516No. of events1,894526316965Multivariable HR (95% CI)† Reference0.93 (0.85–1.03)1.13 (1.00–1.27)0.98 (0.91–1.06)≥ 71 yearsNo. of subjects9,1962,0132,1255,114No. of events1,744315457869Multivariable HR (95% CI)† Reference0.83 (0.74–0.94)1.12 (1.01–1.25)0.89 (0.82–0.96) Reference0.97 (0.89–1.06)1.22 (1.11–1.35)1.15 (1.07–1.23)No. of events (secondary outcome)1,904459359998Multivariable HR (95% CI)† Reference0.98 (0.88–1.08)1.22 (1.11–1.35)1.15 (1.07–1.23)Hip fracturesNo. of events (primary outcome)3536794176Multivariable HR (95% CI)† Reference0.79 (0.61–1.02)1.39 (1.11–1.76)0.98 (0.82–1.18)No. of events (secondary outcome)3396192171Multivariable HR (95% CI)† Reference0.75 (0.57–0.99)1.40 (1.11–1.77)0.99 (0.83–1.20)Humerus & radius fracturesNo. of events (primary outcome)3,8348264031,124Multivariable HR (95% CI)† Reference0.87 (0.80–0.93)1.05 (0.94–1.16)0.85 (0.79–0.91)No. of events (secondary outcome)1,697403202551Multivariable HR (95% CI)† Reference0.95 (0.85–1.06)1.14 (0.98–1.32)0.92 (0.83–1.01)
Table 1 General characteristics of the study population (n = 143,673 women)

Values are presented as mean ± standard deviation not otherwise specified.

BMI, body mass index; WC, waist circumference; CCI, Charlson Comorbidity Index.

Table 2 The association of obesity status with the risk of osteoporotic fractures (primary outcome*)

HR, hazard ratio; CI, confidence interval; BMI, body mass index; WC, waist circumference.

*The primary outcome of this study was defined as having hospitalization for one day or more or physician visits for two times or more within six months under osteoporotic fractures, whichever came the earliest. Osteoporotic fractures include vertebral (S22.0, S22.1, S32.0, M48.4, and M48.5), hip (S72.0 and S72.1), radius (S52.5 and S52.6), and humerus (S42.2 and S42.3) fractures.

†Crude incidence per 1,000 person-years.

‡Adjusted for age, income, smoking status, alcohol habit, regular exercise, bisphosphonate medication, and Charlson Comorbidity Index.

Table 3 Stratified analysis according to age-band for the association of obesity status with the risk of osteoporotic fractures (primary outcome*)

HR, hazard ratio; CI, confidence interval; BMI, body mass index; WC, waist circumference.

*The primary outcome of this study was defined as having hospitalization for one day or more or physician visits for two times or more within six months under osteoporotic fractures, whichever came the earliest. Osteoporotic fractures include vertebral (S22.0, S22.1, S32.0, M48.4, and M48.5), hip (S72.0 and S72.1), radius (S52.5 and S52.6), and humerus (S42.2 and S42.3) fractures.

†Adjusted for age, income, smoking status, alcohol habit, regular exercise, bisphosphonate medication, and Charlson Comorbidity Index.

Table 4 Subgroup analysis according to the type of osteoporotic fractures according to primary and secondary outcomes*

HR, hazard ratio; CI, confidence interval; BMI, Body mass index (kg/m2); WC, waist circumference (cm)

*The primary outcome of this study was defined as having hospitalization for one day or more or physician visits for two times or more within six months under osteoporotic fractures, whichever came the earliest. The secondary outcome was osteoporotic fractures requiring hospitalization for two days or more, as a marker for severe fractures, whichever came the earliest fracture. ICD-10 codes were used to identify and classify fractures: vertebral (S22.0, S22.1, S32.0, M48.4, and M48.5), hip (S72.0 and S72.1), wrist (S52.5 and S52.6), and humerus (S42.2 and S42.3).

†Adjusted for age, income, smoking status, alcohol habit, regular exercise, bisphosphonate medication, and Charlson Comorbidity Index.

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