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Original Article

Probiotic Yogurt Fortified with Vitamin D Can Improve Glycemic Status in Non-Alcoholic Fatty Liver Disease Patients: a Randomized Clinical Trial

Mojgan Morvaridzadeh1orcid, Seyed Mostafa Nachvak2orcid, Reza Mohammadi3orcid, Shima Moradi2orcid, Roghayeh Mostafai1orcid, Ana Beatriz Pizarro4orcid, Hadi Abdollahzad2orcid
Clinical Nutrition Research 2021;10(1):36-47.
Published online: January 22, 2021

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Correspondence to Seyed Mostafa Nachvak. Department of Nutrition, Research Center for Environmental Determinants of Health (RCEDH), Kermanshah University of Medical Sciences, Isar Square, Kermanshah 6719851351, Iran. m.nachvak@kums.ac.ir; smnachvak@hotmail.com
Correspondence to Reza Mohammadi. Department of Food Science and Technology, Research Center for Environmental Determinants of Health (RCEDH), Kermanshah University of Medical Sciences, Isar Square, Kermanshah 6719851351, Iran. r.mohammadi2011@gmail.com
• Received: September 25, 2020   • Revised: December 20, 2020   • Accepted: January 4, 2021

Copyright © 2021. The Korean Society of Clinical Nutrition

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Probiotic Yogurt Fortified with Vitamin D Can Improve Glycemic Status in Non-Alcoholic Fatty Liver Disease Patients: a Randomized Clinical Trial
Clin Nutr Res. 2021;10(1):36-47.   Published online January 22, 2021
DOI: https://doi.org/10.7762/cnr.2021.10.1.36
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Probiotic Yogurt Fortified with Vitamin D Can Improve Glycemic Status in Non-Alcoholic Fatty Liver Disease Patients: a Randomized Clinical Trial
Clin Nutr Res. 2021;10(1):36-47.   Published online January 22, 2021
DOI: https://doi.org/10.7762/cnr.2021.10.1.36
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Probiotic Yogurt Fortified with Vitamin D Can Improve Glycemic Status in Non-Alcoholic Fatty Liver Disease Patients: a Randomized Clinical Trial
Image Image
Figure 1 Study flow chart.PY, probiotic yogurt; Pro-YFD, probiotic yogurt fortified with vitamin D.
Figure 2 Serum level of 25(OH)D3 among 2 studied groups in before and after intervention.Data are represented as below: group A, probiotic-vitamin D fortified yogurt; B, unfortified yogurt.*A p value less than 0.05 is considered statistically significant.

Figure 1

Figure 2

Probiotic Yogurt Fortified with Vitamin D Can Improve Glycemic Status in Non-Alcoholic Fatty Liver Disease Patients: a Randomized Clinical Trial
Table 1 Main characteristics of participants with nonalcoholic fatty liver disease

All values are presented as mean ± standard deviation or number (%).

Data are represented as below: group A, probiotic-vitamin D fortified yogurt; group B, plain yogurt.

BMI, body mass index; WC, waist circumference; WHR, waist-hip ratio; BFM, body fat mass; LBM, lean body mass; PAL, physical activity level.

*p values < 0.05: independent sample t-test and χ2.

Table 2 Energy and nutrients intake of patients with nonalcoholic fatty liver disease

All presented values are means ± standard deviation.

Data are represented as below: group A, probiotic-vitamin D fortified yogurt; group B, plain yogurt; P1, p values denote significance of within-group changes; P2, p values denote significance of between-group difference in the baseline; P3, p values denote significance of between-group difference after intervention.

*Significant difference between groups throughout the study (p < 0.05, independent samples t-test or Mann-Whitney U test).

Table 3 Serum 25(OH)D3, glycemic indices and anthropometric indices of patients with nonalcoholic fatty liver disease

All presented values are means ± standard deviation.

Data are represented as below: group A, probiotic-vitamin D fortified yogurt; group B, plain yogurt; P1, p values denote significance of within-group changes; P2, p values denote significance of between-group difference in the baseline; P3, p values denote significance of between-group difference after intervention.

FBS, fasting blood sugar; HOMA-IR, homeostatic model assessment for insulin resistance; BMI, body mass index; WC, waist circumference; WHR, waist-hip ratio; LBM, lean body mass; SBP, systolic blood pressure; DBP, diastolic blood pressure.

*Significant difference within group throughout the study (p < 0.05, paired samples t-test or Wilcoxon); †Significant difference between groups throughout the study (p < 0.05, independent samples t-test or Mann-Whitney U test).

Table 1

Table 2

Table 3

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