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Original Articles
[English]
Genetic Variations in Thiamin Transferase SLC35F3 and the Risk of Hypertension in Koreans
Ja-young Seo, Jeong-Hwa Choi
Clin Nutr Res 2021;10(2):140-149.   Published online April 19, 2021
DOI: https://doi.org/10.7762/cnr.2021.10.2.140

Hypertension is a major health issues globally. Multiple genetic and environmental factors are involved in hypertension etiology. Solute carrier family 35 member F3 (SLC35F3) is a type of transporter uptakes thiamin across the cellular and mitochondrial membrane. Recent studies suggested that variations in SLC35F3 are associated with the risk of hypertension; however, studies are limited in Koreans. This study examined the association of the genetic variations in SLC35F3 and the risk of hypertension in Koreans using the Korean Genome Epidemiology Study (Ansan/Ansung study). A total of 8,298 Koreans (males 3,983, females 4,315) were analyzed for their general characteristics, dietary intake, and blood pressure. Twenty-four tagging variations in SLC35F3 were selected and investigated for their association with the risk of hypertension using a sex-stratified approach. Findings suggested that, in males, rs12135117 A allele carriers were at the lower risk for hypertension (adjusted odds ratio, 0.859; 95% confidence interval [CI], 0.740–0.998). In females, rs10910387 TC genotype tended to increase the risk 1.172-fold for hypertension (95% CI, 1.002–1.370). Multiple linear regression models exhibited that rs12135117 A allele was negatively associated with blood pressure in males, and rs10910387 TC genotype had a positive association with blood pressure in females. However, statistical significance for these genetically modified effects was in lacked (Bonferroni's corrected p > 0.002). In conclusion, genetic variation in SLC35F3 is not a decisive prediction marker for hypertension risk in Koreans. Given the rarity of data, more studies are required to evaluate the role of SLC35F3 and thiamin in the hypertension etiology.

Citations

Citations to this article as recorded by  
  • Modeling genotype-by-environment interactions across climatic conditions reveals environment-specific genomic regions and candidate genes underlying feed efficiency traits in tropical beef cattle
    João B. Silva Neto, Luiz F. Brito, Lucio F. M. Mota, Gustavo R. D. Rodrigues, Fernando Baldi
    Scientific Reports.2026;[Epub]     CrossRef
  • SLC35 Transporters: The Missing Link Between Glycosylation and Type 2 Diabetes
    Xu Zhang, Hafiza Mahreen Mehwish, Pulin Che
    Diabetology.2026; 7(1): 7.     CrossRef
  • RNA-seq analysis identifies key genes enhancing hoof strength to withstand barefoot racing in Standardbred trotters
    Doreen Schwochow, Asmaa Alameddine, Ellinor Spörndly-Nees, Mathilde Montigny, Rakan Naboulsi, Anna Jansson, Adnan Niazi, Gabriella Lindgren
    BMC Genomics.2025;[Epub]     CrossRef
  • Scoping review of research trends in genetic factors related to metabolic syndrome in Koreans: using the data from Korean Genome and Epidemiology Study (KoGES)
    Minyeong Kim, Subin Kim, Dayeon Shin
    Journal of Nutrition and Health.2025; 58(1): 131.     CrossRef
  • Associations of Serum Thiamine Levels with Blood Pressure Among Middle-Aged and Elderly Women in Eastern China
    Lijin Chen, Jingjing Lin, Xiangyu Chen, Zhimin Ma, Xiaofu Du, Meng Wang, Rong Chen, Jieming Zhong
    Nutrients.2025; 17(13): 2210.     CrossRef
  • The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
    Jie Wei, Yujie Li, Wenqian Zhou, Xiaoya Ma, Jie Hao, Ting Wen, Bin Li, Tianbo Jin, Mingjun Hu
    Open Medicine.2024;[Epub]     CrossRef
  • Unveiling the Enigmatic Role of SLC35F3 in Lung Adenocarcinoma
    Yiwang Ye, Feihu Long, Wei Yue, Zichun Wei, Jianyi Yang, Yuancai Xie
    The Clinical Respiratory Journal.2024;[Epub]     CrossRef
  • Solute Carrier Family 35 (SLC35)—An Overview and Recent Progress
    Shin Kamiyama, Hideyuki Sone
    Biologics.2024; 4(3): 242.     CrossRef
  • Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next-generation sequencing data analysis
    Basavaraj Vastrad, Chanabasayya Vastrad
    Egyptian Journal of Medical Human Genetics.2024;[Epub]     CrossRef
  • Effects of Interaction between SLC35F3 and Carbohydrate Intake on the Incidence of Metabolic Syndrome in Korean Middle-Aged Adults
    Haeun Park, Dayeon Shin
    Nutrients.2023; 15(2): 469.     CrossRef
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[English]

Oxidative stress in eye lens is one of the main causes of the cataract. Dietary antioxidants including vitamin A and C are therefore known to be associated with the risk of the disease. However, evidences are still lacking in Koreans. This study aimed to examine whether dietary vitamin A and C levels are associated with the cataract, using data of Korea National Health and Nutrition Examination Survey 2012. A total of 3,344 individuals (599 cases and 2,745 controls) were analyzed in the study. Dietary data was classified into 3 groups following Dietary Reference Intakes for Koreans 2015: 1) ≤ estimated average requirements (EAR), 2) EAR-recommended nutrient intake (RNI), and 3) ≥ RNI. Findings suggested normal subjects (controls) had better vitamin A and C nutritional status. Vitamin A and C intakes of normal subjects were significantly higher than those of cataract cases (p < 0.001, respectively). Ratio of subjects who consumed vitamin A and C lower than EAR was higher in cataract cases compared to normal subjects (p < 0.001, respectively). These antioxidant intake levels predicted that having lower level of vitamins lower than EAR increased the odd ratios (ORs) for cataract [for vitamin A: OR, 1.89; 95% confidence interval (CI), 1.55–2.31 and for vitamin C: OR, 2.06; 95% CI, 1.69–2.51]. However, such associations were not retained, when the subjects’ demographic and lifestyle factor were adjusted. In conclusion, vitamin A and C showed a protective effect against cataract. However, subjects' life style and demographic factors nullified the association. More studies are required to verify the true association between dietary antioxidants and risk of cataract in Koreans.

Citations

Citations to this article as recorded by  
  • Association between serum magnesium level and long-term prognosis of traumatic brain injury
    Eujene Jung, Jung-Ho Lee, Hyeng-Kyu Park
    Brain Injury.2025; 39(12): 1016.     CrossRef
  • A Review of the Applications of Vitamin C to Treat Human Diseases
    Xiaoke He, Wanting Zhang, Yonglong He, Yuxin Jiang, Jiabing Xu, Wei He
    Pharmaceutical Fronts.2024; 06(04): e406.     CrossRef
  • The association between Dietary Phytochemical Index and Mediterranean-style Dietary Pattern Score with the risk of cataract
    Haniyeh Golafrouz, Farhad Adhami Moghadam, Shahryar Eghtesadi
    PharmaNutrition.2023; 25: 100349.     CrossRef
  • Dietary vitamin A intakes of chinese children with adequate liver stores as assessed by the retinol isotope dilution technique
    Jing Zeng, Yanming Li, Yan Ren, Weiwei Gu, Zhaolin Li, Mei Yang, Bing Xiang
    BMC Pediatrics.2022;[Epub]     CrossRef
  • The Relationship between Nutrient Intake and Cataracts in the Older Adult Population of Korea
    Sangyun Lee, Soyeon Lee, Myeonghyeon Jeong, Sunwoo Jung, Myoungjin Lee, Sunyong Yoo
    Nutrients.2022; 14(23): 4962.     CrossRef
  • ‏Impact of Food Habit on Cataracts Development Among Adults in Aseer Region, Saudi Arabia: A Retrospective Study
    Waleed Aldhabaan, Ahmed S AL-Zomia, Lama A Lahiq, Mushary Alqahtani, Shuruq Al-Qahtani, Sulafah Aljohani, Tariq Al-mufarrih, Yazeed S Alshahrani
    Cureus.2022;[Epub]     CrossRef
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  • 6 Crossref
[English]
Short Term Intake of Undaria pinnatifida Does Not Affect Bone Biomarkers in Young Korean Women with Low Calcium Intake
Clara Yongjoo Park, Bora Lee, Sung Jae Lee
Clin Nutr Res 2020;9(2):90-96.   Published online April 22, 2020
DOI: https://doi.org/10.7762/cnr.2020.9.2.90

Calcium intake is essential for bone health, but young Korean women have low calcium intakes. Seaweeds have high calcium content, which may affect calcium metabolism. Twenty nine females aged 18–39 years with low calcium intake (< 400 mg/day) participated in a 19-day open-label randomized controlled trial. During the first five days, participants adhered to a controlled-feeding protocol followed by a two-week supplementation period in free-living conditions. The treatment group (n = 14) received an additional 200 mg Ca/day through Undaria pinnatifida and Porphyra in meals during the controlled-feeding period, and as U. pinnatifida noodles during days 6–19. Mineral intake (Ca, P, Mg, Na, and K) was assessed from diet composites and three 24-hour recalls during the controlled-feeding and free-living periods, respectively. Fasting serum levels of calcium, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D (1,25[OH]D), phosphorus, parathyroid hormone (PTH), and alkaline phosphatase (ALP) were assessed at baseline, day 6, and day 19. Statistical analyses were performed by Student's t-test and mixed ANOVA. Mean intakes of all minerals during days 1–5 and mean Ca and Mg intakes during days 6–19 were greater in the treatment group compared to the control group. No group effect or group and time interaction was observed in serum biomarkers. Serum 1,25(OH)D increased while PTH and ALP tended to decrease on day 6 but returned to baseline values on day 20. Short-term intake of U. pinnatifida and Porphyra does not affect calcium metabolism in young Korean women with low calcium intakes.

Trial Registration

Clinical Research Information Service Identifier: KCT0003307

Citations

Citations to this article as recorded by  
  • Effects of whole seaweed consumption on humans: current evidence from randomized-controlled intervention trials, knowledge gaps, and limitations
    João P. Trigo, Marie Palmnäs-Bédard, Mar Vall-Llosera Juanola, Ingrid Undeland
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • A short education session increases the accuracy of estimated food records in young Korean women during a controlled-feeding study
    Seunghee Kim, Bora Lee, Clara Yongjoo Park
    Nutrition Research and Practice.2021; 15(5): 613.     CrossRef
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[English]
Association of Nutrient Intakes with Cognitive Function in Koreans Aged 50 years and Older
Hae Lim Kim, Dae-Keun Kim, Seung Wan Kang, Yoo Kyoung Park
Clin Nutr Res 2018;7(3):199-212.   Published online July 26, 2018
DOI: https://doi.org/10.7762/cnr.2018.7.3.199

This study attempted to investigate whether nutrient and food intake were related with mild cognitive impairment (MCI) in adults and elderly over 50 years of age in Korea. Questionnaires and anthropometric measurements were conducted on general aspects of the research, and food frequency questionnaires (FFQs) were conducted to determine nutritional status. The relative theta power (RTP) through electroencephalography (EEG) measurements, neurocognitive function test (NFT; CNS Vital Signs), and cognitive function was measured. The MCI group consumed significantly lower C18:4, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) among the N-3 fatty acids, N-6 fatty acids dihomo-γ-linolenic acid (DGLA), mono unsaturated fatty acids, C22:1, biotin, vitamin D in the nutrients, and sweet potato (12.35g/day, p = 0.015), mackerel (3.38g/day, p = 0.017), mandarin orange (p = 0.016), persimmon (p = 0.013) and apple (p = 0.023) in the food than the normal group did. And the MCI group consumed salted fish (3.14g/day, p = 0.041) and ice-cream (5.01g/day, p = 0.050) at a significantly higher level. Delayed verbal score, delayed visual score, and verbal memory score of the NFT and RTP values of the prefrontal cortex among the EEGs were significantly lower in the MCI group compared to those in the normal group. From this study, we found that nutrient and food intake are closely related to MCI in Korean aged 50 years and older, but more human studies are needed to verify these findings.

Citations

Citations to this article as recorded by  
  • Docosahexaenoic Acid and Nervonic Acid Synergically Enhance Cognitive Memory in Normal Mice via Brain Fatty Acids Remodeling
    Hai‐Yan Ou, Lei Feng, Rui‐Ye Chen, Hui‐Yun Lu, Shuang Cai, Zhi‐You Yang
    eFood.2025;[Epub]     CrossRef
  • Association Between Dietary Biotin Intake and Dementia Risk, Including Alzheimer's Disease: A Prospective Study of 122 959 UK Biobank Participants
    Yan Kong, Jiping Zhong, Tong Wang, Dongfeng Zhang
    Molecular Nutrition & Food Research.2025;[Epub]     CrossRef
  • Diversity and limitations of electroencephalogram and event‐related potential applications in nursing research: A scoping review
    Huiling Hu, Bilin Wu, Huijun Li, Binlin Wang, Xue Wu
    Japan Journal of Nursing Science.2024;[Epub]     CrossRef
  • Dietary factors in relation to the risk of cognitive impairment and physical frailty in Chinese older adults: a prospective cohort study
    Liyan Huang, Hui Chen, Mengyan Gao, Jie Shen, Yang Tao, Yuhui Huang, Rongxia Lv, Renxiang Xie, Xiaozhen Lv, Xin Xu, Xiaolin Xu, Changzheng Yuan
    European Journal of Nutrition.2024; 63(1): 267.     CrossRef
  • Znaczenie kwasu dokozaheksaenowego (DHA) w prewencji zaburzeń funkcji poznawczych u osób starszych
    Agata Białecka-Dębek, Dominika Granda, Barbara Pietruszka
    Postępy Higieny i Medycyny Doświadczalnej.2021; 75(1): 345.     CrossRef
  • Dermatitis Neglecta, the Cognitive Assessment, and Micronutrients
    Thomas M. Brown
    Psychosomatics.2020; 61(6): 723.     CrossRef
  • Beta wave enhancement neurofeedback improves cognitive functions in patients with mild cognitive impairment
    Jung-Hee Jang, Jieun Kim, Gunhyuk Park, Haesook Kim, Eun-Sun Jung, Ji-yun Cha, Chan-young Kim, Siyeon Kim, Jun-Hwan Lee, Horyong Yoo
    Medicine.2019; 98(50): e18357.     CrossRef
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  • 7 Crossref