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"Jin Cho"

Original Article

[English]
Effects of Melissa officinalis Extracts on Obesity and Anxiety
Jin Gyeom Kim, Jiye Park, Sooyeon Baek, Seunghyun Won, Jin Cho
Clin Nutr Res 2025;14(1):65-77.   Published online January 31, 2025
DOI: https://doi.org/10.7762/cnr.2025.14.1.65

Obesity is a significant global health concern that not only increases metabolic disorders risks but also impacts mental health, particularly affecting women due to hormonal fluctuations and societal pressures. This study investigated anti-obesity and anti-anxiety effects of lemon balm (Melissa officinalis) extracts in female C57BL/6 mouse (n = 16, 17 weeks old) fed a high-fat diet (HFD). We compared 2 extracts method: distilled water (LBD, n = 5) and 80% ethanol (LBE, n = 6), administered via oral gavage (200 mg/kg/day) for 6 weeks alongside HFD. Both extract groups showed lower weight increase ratio compared to the control group in experiment period (n = 5) (LBD: 27.74%, LBE: 29.71% vs. Control: 51.88%, p < 0.05). The extracts significantly decreased mesenteric white adipose tissue (mWAT) among WATs examined (mWAT and parametrial white adipose tissue [pWAT]). While both LBD and LBE reduced fatty acid synthase (FAS) mRNA expression in pWAT, only LBD reduced peroxisome proliferator-activated receptor gamma and FAS mRNA expression in mWAT. In elevated plus maze behavioral experiments, the LBD group displayed reduced anxiety-like behavior, spending significantly more time and travelling greater distances in the open arms compared to other groups (p < 0.05), independent of brain inflammatory markers. Our findings demonstrate lemon balm extracts simultaneously address both obesity and anxiety-like behaviors in female mice, with extraction solvent-dependent variations in efficacy and mechanism of action. These results suggest potential therapeutic applications for lemon balm as a functional food ingredient, particularly for women experiencing concurrent obesity and anxiety symptoms.

Citations

Citations to this article as recorded by  
  • Differential impacts of high-intensity interval training and moderate-intensity continuous training on obesity-induced behavioral and biochemical dysregulation in male mice
    Hossein Nazari, Ayoob Sabaghi, Ershad Nedaei, Namdar Yousofvand
    Sport Sciences for Health.2025; 21(3): 1673.     CrossRef
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Review Articles
[English]
Nutritional Factors Affecting Mental Health
So Young Lim, Eun Jin Kim, Arang Kim, Hee Jae Lee, Hyun Jin Choi, Soo Jin Yang
Clin Nutr Res 2016;5(3):143-152.   Published online July 26, 2016
DOI: https://doi.org/10.7762/cnr.2016.5.3.143

Dietary intake and nutritional status of individuals are important factors affecting mental health and the development of psychiatric disorders. Majority of scientific evidence relating to mental health focuses on depression, cognitive function, and dementia, and limited evidence is available about other psychiatric disorders including schizophrenia. As life span of human being is increasing, the more the prevalence of mental disorders is, the more attention rises. Lists of suggested nutritional components that may be beneficial for mental health are omega-3 fatty acids, phospholipids, cholesterol, niacin, folate, vitamin B6, and vitamin B12. Saturated fat and simple sugar are considered detrimental to cognitive function. Evidence on the effect of cholesterol is conflicting; however, in general, blood cholesterol levels are negatively associated with the risk of depression. Collectively, the aims of this review are to introduce known nutritional factors for mental health, and to discuss recent issues of the nutritional impact on cognitive function and healthy brain aging.

Citations

Citations to this article as recorded by  
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    BMC Geriatrics.2025;[Epub]     CrossRef
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    Physiology & Behavior.2025; 291: 114798.     CrossRef
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    Aleksandra Kołodziejczyk, Justyna Nowak
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    Enid A. Keseko, Gabrielle M. Turner-McGrievy, John A. Bernhart, Alexis Bell, Shiba Bailey, Ye S. Kim, Nkechi Okpara, Sara Wilcox, Edward A. Frongillo
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[English]
Nutritional Care of Gastric Cancer Patients with Clinical Outcomes and Complications: A Review
Wook Jin Choi, Jeongseon Kim
Clin Nutr Res 2016;5(2):65-78.   Published online April 30, 2016
DOI: https://doi.org/10.7762/cnr.2016.5.2.65

The incidence and mortality of gastric cancer have been steadily decreased over the past few decades. However, gastric cancer is still one of the leading causes of cancer deaths across many regions of the world, particularly in Asian countries. In previous studies, nutrition has been considered one of significant risk factors in gastric cancer patients. Especially, malnourished patients are at greater risk of adverse clinical outcomes (e.g., longer hospital stay) and higher incidence of complications (e.g., wound/infectious complications) compared to well-nourished patients. Malnutrition is commonly found in advanced gastric cancer patients due to poor absorption of essential nutrients after surgery. Therefore, nutritional support protocols, such as early oral and enternal feeding, have been proposed in many studies, to improve unfavorable clinical outcomes and to reduce complications due to delayed application of oral nutritional support or parental feeding. Also, the supplied with enternal immune-enriched diet had more benefits in improving clinical outcomes and fewer complications compared to a group supplied with control formula. Using nutritional screening tools, such as nutritional risk index (NRI) and nutritional risk screening (NRS 2002), malnourished patients showed higher incidence of complications and lower survival rates than non-malnourished patients. However, a long-term nutritional intervention, such as nutritional counseling, was not effective in the patients. Therefore, early assessment of nutritional status in patients using a proper nutritional screening tool is suggested to prevent malnutrition and adverse health outcomes. Further studies with numerous ethnic groups may provide stronger scientific evidences in association between nutritional care and recovery from surgery in patients with gastric cancer.

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[English]
Dietary Factors and the Risk of Thyroid Cancer: A Review
Wook Jin Choi, Jeongseon Kim
Clin Nutr Res 2014;3(2):75-88.   Published online July 29, 2014
DOI: https://doi.org/10.7762/cnr.2014.3.2.75

In the past few decades, the incidence of thyroid cancer has rapidly increased worldwide. Thyroid cancer incidence is relatively high in regions where the population's daily iodine intake is insufficient. While low dietary iodine has been considered as a risk factor for thyroid cancer development, previous studies found controversial results across different food types. Among different ethnic groups, dietary factors are influenced by various dietary patterns, eating habits, life-styles, nutrition, and other environmental factors. This review reports the association between dietary factors and thyroid cancer risk among ethnic groups living in different geologic regions. Iodine-rich food such as fish and shellfish may provide a protective role in populations with insufficient daily iodine intake. The consumption of goitrogenic food, such as cruciferous vegetables, showed a positive association with risk. While considered to be a risk factor for other cancers, alcohol intake showed a protective role against thyroid cancer. High consumption of meat such as chicken, pork, and poultry showed a positive association with the risk, but dairy products showed no significant association. Regular use of multivitamins and dietary nitrate and nitrite also showed a positive association with thyroid cancer risk. However, the study results are inconsistent and investigations into the mechanism for how dietary factors change thyroid hormone levels and influence thyroid function are required.

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