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"Anxiety"

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"Anxiety"

Original Articles

[English]
Food Quality Is Associated With Depression, Anxiety, and Stress Among Recovered COVID-19 Patients: Finding From a Case-Control Study
Hanieh Barghchi, Asie Araste, Naeimeh Varasteh, Zahra Dehnavi, Reza Zare-Feyzabadi, Mohammad Vahedi Fard, Kimia MohammadHasani, Javad Parirokh, Zahra Khorasanchi, Maryam Mohammadi Bajgiran, Elahe Hasanzadeh, Reyhaneh Ebrahimi, Malihe Aghasizadeh, Mansoureh Sadat Ekhteraee Toosi, Parisa Asadian-Sohan, Reza Assaran Darban, Reza Hossieni, Gordon Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan
Clin Nutr Res 2025;14(1):17-29.   Published online February 5, 2025
DOI: https://doi.org/10.7762/cnr.2025.14.1.17

Following up with recovered coronavirus disease 2019 (COVID-19) patients is necessary. Given the importance of psychological function accompanied by significant effects of food quality, we want to examine the association between food quality score (FQS) and mental disorders among recovered COVID-19 patients. This case-control study was performed on 246 eligible adults. A validated food frequency questionnaire (FFQ) was used to evaluate dietary intake. We using Depression Anxiety Stress Scales, Insomnia Severity Index, Pittsburgh Sleep Quality Index, and 36-Item Short Form Health Survey questionnaires to evaluate the psychological function. Logistic regression analysis was conducted to estimate the odds ratio (OR) and 95% confidence intervals (CIs) for score categories of the FQS index and psychological function in multivariate-adjusted models. Only in case subjects, we found significant associations between adherence to the FQS diet and depression, anxiety, and stress in the crude model (OR, 0.796, 95% CI, 0.661–0.958, p = 0.016; OR, 0.824, 95% CI, 0.707–0.960, p = 0.013; OR, 0.824, 95% CI, 0.709–0.956, p = 0.011, respectively). These associations remained significant in all two adjusted models. However, no significant associations were found between FQS and psychological functions in the control group. Our data suggests that overall food quality intake is associated with depression, anxiety, and stress symptoms during the post-infection period. Also, adequate daily intakes of fruits, legumes, nuts, and whole grains are associated with reduced risks of psychological impairment and sleep disorders which are common among recovered patients.

Citations

Citations to this article as recorded by  
  • Digestive Manifestations of Post-COVID-19: A Focus on Therapeutic Strategies
    Cristina Stasi, Massimo Bellini
    Pathogens.2025; 14(6): 555.     CrossRef
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  • 1 Crossref
[English]
Effects of Melissa officinalis Extracts on Obesity and Anxiety
Jin Gyeom Kim, Jiye Park, Sooyeon Baek, Seunghyun Won, Jin Cho
Clin Nutr Res 2025;14(1):65-77.   Published online January 31, 2025
DOI: https://doi.org/10.7762/cnr.2025.14.1.65

Obesity is a significant global health concern that not only increases metabolic disorders risks but also impacts mental health, particularly affecting women due to hormonal fluctuations and societal pressures. This study investigated anti-obesity and anti-anxiety effects of lemon balm (Melissa officinalis) extracts in female C57BL/6 mouse (n = 16, 17 weeks old) fed a high-fat diet (HFD). We compared 2 extracts method: distilled water (LBD, n = 5) and 80% ethanol (LBE, n = 6), administered via oral gavage (200 mg/kg/day) for 6 weeks alongside HFD. Both extract groups showed lower weight increase ratio compared to the control group in experiment period (n = 5) (LBD: 27.74%, LBE: 29.71% vs. Control: 51.88%, p < 0.05). The extracts significantly decreased mesenteric white adipose tissue (mWAT) among WATs examined (mWAT and parametrial white adipose tissue [pWAT]). While both LBD and LBE reduced fatty acid synthase (FAS) mRNA expression in pWAT, only LBD reduced peroxisome proliferator-activated receptor gamma and FAS mRNA expression in mWAT. In elevated plus maze behavioral experiments, the LBD group displayed reduced anxiety-like behavior, spending significantly more time and travelling greater distances in the open arms compared to other groups (p < 0.05), independent of brain inflammatory markers. Our findings demonstrate lemon balm extracts simultaneously address both obesity and anxiety-like behaviors in female mice, with extraction solvent-dependent variations in efficacy and mechanism of action. These results suggest potential therapeutic applications for lemon balm as a functional food ingredient, particularly for women experiencing concurrent obesity and anxiety symptoms.

Citations

Citations to this article as recorded by  
  • Differential impacts of high-intensity interval training and moderate-intensity continuous training on obesity-induced behavioral and biochemical dysregulation in male mice
    Hossein Nazari, Ayoob Sabaghi, Ershad Nedaei, Namdar Yousofvand
    Sport Sciences for Health.2025; 21(3): 1673.     CrossRef
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  • 1 Crossref

Review Article

[English]
The Effect of Oral Chamomile on Anxiety: A Systematic Review of Clinical Trials
Sogand Saadatmand, Foad Zohroudi, Hadith Tangestani
Clin Nutr Res 2024;13(2):139-147.   Published online April 23, 2024
DOI: https://doi.org/10.7762/cnr.2024.13.2.139

Anxiety disorder is a prevalent psychiatric issue that affects 4.05% of the global population. As complementary and alternative medicine gains popularity, many individuals with anxiety symptoms seek herbal remedies. This systematic review aims to explore the sedative efficacy of chamomile as an herbal medicine for anxiety treatment. Our search was conducted in PubMed, Google Scholar, and Scopus databases until August 2023. Among 389 papers found, after removing duplicates and irrelevant papers, 10 clinical trials investigating the effect of oral consumption of chamomile on anxiety were included. Two researchers independently completed all steps, including the screening process and data extraction. Out of the 10 articles selected, 9 studies have concluded that chamomile is effective in reducing anxiety. Even though, the exact mechanism of chamomile’s anxiolytic action is not well understood, evidence suggests that its active compounds, including apigenin, may modulate the function of the hypothalamic-pituitary-adrenocortical axis by affecting neurotransmitter pathways. This systematic review showed that chamomile potentially has an anxiolytic effect. In addition, due to the side effects of drugs used to treat anxiety disorders, the use of chamomile seems to be effective and less dangerous.

Citations

Citations to this article as recorded by  
  • Phytochemicals from edible flowers prevent neurodegenerative diseases via the gut-brain axis
    Fatemeh Abbaszadeh, Sajad Fakhri, Behrang Shiri Varnamkhasti, Seyed Zachariah Moradi, Mohammad Reza Khirehgesh, Javier Echeverría
    Food Bioscience.2025; 63: 105681.     CrossRef
  • Medicinal Plants and Herbal Medicines for Managing Anxiety and Depression via Gut Microbiota Modulation
    Priscilla Magro Reque, Adriano Brandelli, Cristina Mayumi Sasaki Miyazaki, Ana Flávia Marçal Pessoa, Jian. Wu
    Advanced Gut & Microbiome Research.2025;[Epub]     CrossRef
  • Neurocosmetics and Aromatherapy Through Neurocutaneous Receptors and Their Functional Implications in Cosmetics
    María Judith Sánchez-Peña, Odessa Magallón-Chávez, Juan Antonio Rivas-Loaiza
    Cosmetics.2025; 12(5): 179.     CrossRef
  • The Effect of Chamomile on Common Psychological Disorders Including Depression, Anxiety, Stress and Sleep Disorders: A Narrative Review
    Atena Pasban, Motahareh Yadegari, Zahra Rahimi-Nasrabad, Setayesh Saadati-Partan, Fatemeh Jafarzadeh-Sekeh, Sosan Sadeghi, Zohreh Sadat Sangsefidi
    Iranian Journal of Psychiatry and Behavioral Sciences.2025;[Epub]     CrossRef
  • Neuroactive Phytochemicals as Multi-Target Modulators of Mental Health and Cognitive Function: An Integrative Review
    Halina Tkaczenko, Lyudmyla Buyun, Renata Kołodziejska, Piotr Kamiński, Natalia Kurhaluk
    International Journal of Molecular Sciences.2025; 26(18): 8907.     CrossRef
  • Effect of Raha syrup on the motivational effects of morphine and CSF serotonin levels in rats
    Mitra As’habi, Mahdi Zahedi-Khorasani, Freshteh Haerifar, Ali Ghanbari, Ali khaleghian, Hossein Miladi-Gorji
    Learning and Motivation.2024; 88: 102063.     CrossRef
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  • 6 Crossref
Original Article
[English]
Association of the Anxiety/Depression with Nutrition Intake in Stroke Patients
Yoonji Kim, Myung-chul Kim, Hang-Sik Park, Il-Hoon Cho, Jean Kyung Paik
Clin Nutr Res 2018;7(1):11-20.   Published online January 30, 2018
DOI: https://doi.org/10.7762/cnr.2018.7.1.11

Stroke patients often experience a walking dysfunction caused by decreased mobility, weakened muscular strength, abnormal posture control, and cognitive dysfunction. Anxiety/depression is the most important and prevalent neuropsychiatric complication of stroke survivors. Brain injury and the presence of malnutrition after stroke contribute to metabolic status and clinical outcome of patients. We examined the level of nutrition intake in stroke patients according to their degree of anxiety/depression. The data were obtained from 2013 to 2015 through the Korea National Health and Nutrition Examination Survey (KNHANES). Study subjects were categorized to either a group having no problem of anxiety/depression (n = 274) or a group having a problem of anxiety or depression (n = 104). The EuroQoL-5 Dimensions Health Questionnaire (EQ-5D) index score was derived from the first description of an individual health status based on the EQ-5D classification system, including mobility, self-care, usual daily activities, pain/discomfort, and anxiety/depression. The mean age was 67.4 years in the normal group and 68.0 years in the anxiety or depression group. In the anxiety or depression group, 39.4% were men vs. 53.3% in the normal group. The total energy intake (p = 0.013), riboflavin (p = 0.041), and niacin (p = 0.038) was significantly higher in stroke patients with no anxiety/depression than those in stroke patients with having an anxiety/depression. The group having no problem of anxiety/depression had significantly higher EQ-5D index compared to the group having a problem of anxiety/depression group (p < 0.001) had. The results suggest the association between nutrition intake, usual activities and pain/discomfort status in the stroke patients with having an anxiety/depression.

Citations

Citations to this article as recorded by  
  • Effect of electroacupuncture on metabolic alterations in the hippocampus and dorsal raphe nucleus of Wistar Kyoto rats
    Xiaoling Zeng, Xuan Yin, Kaiyu Cui, Wenqing Xu, Xiang Li, Wei Zhang, Wei Li, Shifen Xu
    Brain Research.2025; 1850: 149409.     CrossRef
  • A Lower Energy Balance is Associated With Higher Severity and Odd of Depression Based on the Beck Depression Inventory‐13 (BDI‐13) in a Retiring Age Population: A Population‐Based Cross‐Sectional Study
    Mohammad Reza Shadmand Foumani Moghadam, Mostafa Shahraki Jazinaki, Zohre Hosseini, Fatemeh Rajabi, Sharif Etemdi, Melika Hadizadeh, Parnian Pezeshki, Mohammad Amushahi, Reza Rezvani
    Health Science Reports.2025;[Epub]     CrossRef
  • The effects of visual information deprivation and feedback balance training on balance in patients with stroke
    Taewoong Jeong, Yijung Chung
    NeuroRehabilitation.2024; 54(3): 435.     CrossRef
  • Health-related quality of life and its associated factors among Chinese seasonal retired migrants in Hainan
    Sikun Chen, Tianchang Li, Lingjun Wang, Shigong Wang, Lin Ouyang, Jiwei Wang, Dayi Hu, Jinming Yu
    PeerJ.2024; 12: e18574.     CrossRef
  • Association between malnutrition, depression, anxiety and fatigue after stroke in older adults: a cross-lagged panel analysis
    Hongmei Huang, Mengxia Lu, Pan Zhang, Lulu Xiao, Wanqiu Zhang, Yingjie Xu, Jinghui Zhong, Yiran Dong, Xian Chao, Yirong Fang, Jinjing Wang, Shiyi Jiang, Wusheng Zhu, Xinfeng Liu, Wen Sun
    Aging Clinical and Experimental Research.2024;[Epub]     CrossRef
  • Malnutrition and poststroke depression in patients with ischemic stroke
    Mengmeng Gu, Jinjing Wang, Lulu Xiao, Xiangliang Chen, Meng Wang, Qing Huang, Junshan Zhou, Wen Sun
    Journal of Affective Disorders.2023; 334: 113.     CrossRef
  • Herramientas diagnósticas nutricionales en pacientes con discapacidad. Artículo de revisión
    Diana María Igua-Ropero
    Revista Médicas UIS.2022;[Epub]     CrossRef
  • Association between Geriatric Nutritional Risk Index and Depression after Ischemic Stroke
    Jianian Hua, Jieyi Lu, Xiang Tang, Qi Fang
    Nutrients.2022; 14(13): 2698.     CrossRef
  • Effects of Visual Cue Deprivation Balance Training with Head Control on Balance and Gait Function in Stroke Patients
    Seung-Min Nam, Do-Youn Lee
    Medicina.2022; 58(5): 629.     CrossRef
  • Health State Utility Values in People With Stroke: A Systematic Review and Meta‐Analysis
    Raed A. Joundi, Joel Adekanye, Alexander A. Leung, Paul Ronksley, Eric E. Smith, Alexander D. Rebchuk, Thalia S. Field, Michael D. Hill, Stephen B. Wilton, Lauren C. Bresee
    Journal of the American Heart Association.2022;[Epub]     CrossRef
  • Exercise intervention for sleep disorders after stroke
    Qin Zhang, Yi Liu, Yin Liang, Dan Yang, Wei Zhang, Liqun Zou, Zhi Wan
    Medicine.2021; 100(17): e25730.     CrossRef
  • Health-related quality of life profiles and their dimension-specific associated factors among Malaysian stroke survivors: a cross sectional study
    Hui Jie Wong, Pei Lin Lua, Sakinah Harith, Khairul Azmi Ibrahim
    Health and Quality of Life Outcomes.2021;[Epub]     CrossRef
  • A DEFICIÊNCIA DE TIAMINA E NIACINA COMO FATOR DE RISCO PARA DE DOENÇAS NEUROLÓGICAS
    Nayrene Amorin Carvalho Oliveira, Laryssa Alves Magalhães, Maria Rosimar Teixeira Matos, Gislei Frota Aragão, Tatiana Paschoalette Rodrigues Bachur
    Infarma - Ciências Farmacêuticas.2019; 31(2): 80.     CrossRef
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  • 13 Crossref