Nigella sativa (N. sativa) is one of important herbal foods in traditional medicine and many studies have conducted to show the effects of this plant on several diseases. The goal of this study was the evaluation of effects of bread with N. Sativa on clinical parameters such as blood glucose, blood pressure (BP) and anthropometry indices in subjects with metabolic syndrome (MetS). A study as double-blind, cross-over, randomized clinical trial was performed in 51 MetS patients in Chalus, north region of Iran. After dividing of patients randomly in 2 groups, in phase 1, intervention group (A, n = 27) used daily a bread with N. sativa and control group (B, n = 24) used the same bread but without N. sativa for 2 months. After considering of 15 day wash out period, phase 2 was began with changing of position of 2 groups. Measuring of parameters including fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP), weight, body mass index (BMI), and waist circumference (WC) was done before and after of 2 phases. After evaluation of treatment, sequence and time effects of intervention on parameters, it is shown that consumption of this bread has not significant treatment effect (as main effect) on FBG, SBP, DBP, WC, weight, and BMI (p > 0.05). Sequence effect on FBG, weight, WC, and BMI was significant (p < 0.05), but was not on BP. Time effect was only significant for DBP. Consumption of bread with N. sativa in MetS patients has not significant effect on FBG, BP, weight, WC, and BMI.

Citations

Citations to this article as recorded by  

• Effect of Nigella sativa Consumption on Lipid Profile and Glycemic Index in Patients with Metabolic Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials
  Maryam Shabani, Farideh Ghavidel, Arezoo Rajabian, Masoud Homayouni-Tabrizi, Tannaz Jamialahmadi, Hossein Hosseini, Amirhossein Sahebkar
  Current Medicinal Chemistry.2025; 32(18): 3638.     CrossRef
• Designing novel industrial and functional foods using the bioactive compounds from Nigella sativa L. (black cumin): Biochemical and biological prospects toward health implications
  Muhammad H. Alu'datt, Taha Rababah, Doa'a G. F. Al‐u'datt, Sana Gammoh, Sharifa Alkandari, Ahmed Allafi, Mohammad Alrosan, Stan Kubow, Haneen K. Al‐Rashdan
  Journal of Food Science.2024; 89(4): 1865.     CrossRef
• Application of Nigella sativa as a functional food in diabetes and related complications: Insights on molecular, cellular, and metabolic effects
  Habibeh Mashayekhi-Sardoo, Samaneh Sepahi, Vafa Baradaran Rahimi, Vahid Reza Askari
  Journal of Functional Foods.2024; 122: 106518.     CrossRef
• Natural products for managing metabolic syndrome: a scoping review
  Mohammed Faris Abdulghani, Sadeq Al-Fayyadh
  Frontiers in Pharmacology.2024;[Epub]     CrossRef
• The effects of Nigella sativa on anthropometric indices: A GRADE-assessed systematic review and dose–response meta-analysis of controlled trials
  Mahdi Vajdi, Melika Darzi, Hadi Bazyar, Zahra Hajhashemy, Shirin Hassanizadeh, Arash Karimi, Gholamreza Askari
  Journal of Functional Foods.2023; 103: 105472.     CrossRef
• The Effect of Regular Consumption of Reformulated Breads on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
  Alena M. Schadow, Ingrid Revheim, Ulrike Spielau, Jutta Dierkes, Lukas Schwingshackl, Jan Frank, Jonathan M. Hodgson, André Moreira-Rosário, Chris J. Seal, Anette E. Buyken, Hanne Rosendahl-Riise
  Advances in Nutrition.2023; 14(1): 30.     CrossRef
• A Scoping Review of the Clinical Evidence for the Health Benefits of Culinary Doses of Herbs and Spices for the Prevention and Treatment of Metabolic Syndrome
  Marion Mackonochie, Ana Rodriguez-Mateos, Simon Mills, Vivien Rolfe
  Nutrients.2023; 15(23): 4867.     CrossRef
• Herbal Therapies for Weight Gain and Metabolic Abnormalities Induced by Atypical Antipsychotics: A Review Article
  Hamideh Naghibi, Roshanak Salari, Mahdi Yousefi, Majid Khadem-Rezaiyan, Mohammad Reza Ghanbarzadeh, Mohammad Reza Fayyazi Bordbar
  Current Drug Discovery Technologies.2023;[Epub]     CrossRef
• Antihypertensive effects of Nigella sativa supplementation: An updated systematic review and meta‐analysis of randomized controlled trials
  Zeynab Kavyani, Vali Musazadeh, Ehsan Safaei, Mina Mohammadi Asmaroud, Fatemeh Khashakichafi, Sana Sedgh Ahrabi, Parvin Dehghan
  Phytotherapy Research.2023; 37(8): 3224.     CrossRef
• Predicting the Occurrence of Metabolic Syndrome Using Machine Learning Models
  Maria Trigka, Elias Dritsas
  Computation.2023; 11(9): 170.     CrossRef
• Metabolic syndrome; Definition, Pathogenesis, Elements, and the Effects of medicinal plants on it’s elements
  Musaab Ahmed, Nisha Kumari, Zainelabdin Mirgani, Amal Saeed, Azza Ramadan, Mohamed H Ahmed, Ahmed Omer Almobarak
  Journal of Diabetes & Metabolic Disorders.2022; 21(1): 1011.     CrossRef
• Nigella Sativa (Black seeds) – Potential Herb to Help Weight Loss
  Naina Mohamed Pakkir Maideen
  Current Traditional Medicine.2022;[Epub]     CrossRef
• Black Seeds
  Keith W. Singletary
  Nutrition Today.2022; 57(6): 348.     CrossRef
• Nigella Plants – Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies
  Bahare Salehi, Cristina Quispe, Muhammad Imran, Iahtisham Ul-Haq, Jelena Živković, Ibrahim M. Abu-Reidah, Surjit Sen, Yasaman Taheri, Krishnendu Acharya, Hamed Azadi, María del Mar Contreras, Antonio Segura-Carretero, Dima Mnayer, Gautam Sethi, Miquel Mar
  Frontiers in Pharmacology.2021;[Epub]     CrossRef
• Effects of Nigella sativa on Performance, Blood Profiles, and Antibody Titer against Newcastle Disease in Broilers
  Alireza Talebi, Masoud Maham, Siamak Asri-Rezaei, Pouya Pournaghi, Mohammad-Sadegh Khorrami, Amir Derakhshan, Valeria Sülsen
  Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1.     CrossRef
• Black Cumin Pressing Waste Material as a Functional Additive for Starch Bread
  Renata Różyło, Jolanta Piekut, Monika Wójcik, Katarzyna Kozłowicz, Marzena Smolewska, Marta Krajewska, Marek Szmigielski, Hayat Bourekoua
  Materials.2021; 14(16): 4560.     CrossRef
• The effect of Nigella sativa on appetite, anthropometric and body composition indices among overweight and obese women: A crossover, double-blind, placebo-controlled, randomized clinical trial
  Sara Safi, Elham Razmpoosh, Hossien Fallahzadeh, Mahta Mazaheri, Nooshin Abdollahi, Majid Nazari, Azadeh Nadjarzadeh, Amin Salehi-Abargouei
  Complementary Therapies in Medicine.2021; 57: 102653.     CrossRef
• Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials
  Jamal Hallajzadeh, Alireza Milajerdi, Moein Mobini, Elaheh Amirani, Susan Azizi, Elhameh Nikkhah, Babak Bahadori, Razieh Sheikhsoleimani, Seyyed Mehdi Mirhashemi
  Phytotherapy Research.2020; 34(10): 2586.     CrossRef
• Nigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study
  Amit S. Rao, Shyamala Hegde, Linda M. Pacioretty, Jan DeBenedetto, John G. Babish
  Journal of Medicinal Food.2020; 23(9): 905.     CrossRef